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Igf2 Conditional Knockout mouse models
Igf2 is the mouse ortholog of human IGF2 and encodes a fetal growth factor whose expression is paternally monoallelic under control of the H19 imprinting control region through CTCF-dependent enhancer competition, with additional input from intragenic differentially methylated regions. The mature peptide signals through IGF1R and, distinctively, through the insulin receptor A isoform, while IGF2R clears it from circulation, making its dosage unusually sensitive to both imprinting status and receptor stoichiometry. Human loss of imprinting drives Beckwith-Wiedemann overgrowth and Wilms tumor, whereas hypomethylation reduces growth in Silver-Russell syndrome, a bidirectional disease logic that allele design should mirror: a paternal-allele conditional null tests the growth requirement, imprinting control region deletion or targeted methylation alleles model biallelic expression, and humanization supports antibody or ligand trap testing. Because Igf1 covers much of postnatal growth, phenotypes concentrate prenatally. Match allele to embryonic and placental growth measurement, allele-specific expression assays, and tumor incidence.
Conditional deletion of Igf2 limits the genetic change to the lineage you choose. That helps in oncology, immunology, and metabolic work where systemic loss would muddy the read. After you confirm Cre specificity, crossing to Igf2 floxed stock yields usable cohorts.
What Igf2 Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Igf2 conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Igf2-Flox | CKO | CKO | IN PRODUCTION | CKO 253835 | Inquire |
| These mice carry loxP sites flanking exon 2-4 of Igf2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Igf2 gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Igf2 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Igf2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Igf2 Conditional Knockout mouse models are available?
When Igf2 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Igf2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Igf2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Igf2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Igf2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Igf2 Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.