Il17f Knockin mouse models
Sharing a cystine-knot fold and receptor with interleukin 17A, the product of Il17f, mouse ortholog of human IL17F, signals through IL-17RA and IL-17RC with roughly an order of magnitude lower potency and circulates as a homodimer or as an interleukin 17A and 17F heterodimer, converging on Act1, TRAF6, and NF-kB driven neutrophil chemokine and antimicrobial peptide induction at barrier surfaces. The human S65L variant behaves as a dominant negative and causes chronic mucocutaneous candidiasis, establishing a genuine disease knockin design distinct from a simple null, while murine gut phenotypes indicate nonredundant roles in microbiota containment. Because the adjacent Il17a locus is coregulated and functionally overlapping, an Il17f single null typically produces mild readouts, and compound Il17a with Il17f deletion or Il17ra deletion is required for confident loss-of-function conclusions. Match allele to endpoint: dominant negative knockins for host defense, humanization for bimekizumab-class dual blockade, and lineage restricted Cre for source attribution.
Targeting Il17f preserves positional context compared with viral or BAC approaches. That helps when you quantify expression or map chromatin.
What Il17f Knockin mouse models are available?
ingenious targeting laboratory offers 1 distinct Il17f knockin catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Il17f-Luc-2A-EGFP | Knockin | fluorescent mouse | embryo cryopreservation | KI 00031 | Inquire |
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The Il17f Knockin lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Il17f allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Il17f Knockin mouse models are available?
When Il17f Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Il17f knockout embryonic lethal in mice?
It depends on background and allele design. Some Il17f germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Il17f animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Il17f?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.