Conventional / global / constitutive KO
●4 Models Available
Il17f Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Il17f mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Il17f conditional knockout mouse, Il17f knockin mouse, Il17f knockout mouse. Contact us for availability and fast turnaround.
Why model Il17f
Sharing a cystine-knot fold and receptor with interleukin 17A, the product of Il17f, mouse ortholog of human IL17F, signals through IL-17RA and IL-17RC with roughly an order of magnitude lower potency and circulates as a homodimer or as an interleukin 17A and 17F heterodimer, converging on Act1, TRAF6, and NF-kB driven neutrophil chemokine and antimicrobial peptide induction at barrier surfaces. The human S65L variant behaves as a dominant negative and causes chronic mucocutaneous candidiasis, establishing a genuine disease knockin design distinct from a simple null, while murine gut phenotypes indicate nonredundant roles in microbiota containment. Because the adjacent Il17a locus is coregulated and functionally overlapping, an Il17f single null typically produces mild readouts, and compound Il17a with Il17f deletion or Il17ra deletion is required for confident loss-of-function conclusions. Match allele to endpoint: dominant negative knockins for host defense, humanization for bimekizumab-class dual blockade, and lineage restricted Cre for source attribution.
What Il17f mouse models are available?
ingenious targeting laboratory offers 4 distinct Il17f (IL17F) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il17f model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il17f allele types
Knockout, conditional, knockin, humanized, and related paths for Il17f (human IL17F). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il17f catalog models
4 Il17f lines with QC documentation and technical support. Il17f floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Il17f mouse model?
We have 4 Il17f models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il17f Mouse Model Types
A Il17f knockout mouse has the Il17f gene permanently inactivated, enabling loss of function studies. A Il17f conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il17f, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il17f knockin models carry a precisely inserted sequence at the Il17f locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il17f organized by modification type. Each URL is indexable and matches common search patterns.