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Il2 Immunodeficient mouse models
Il2 is the mouse ortholog of human IL2 and encodes a four alpha helix bundle cytokine that assembles a trimeric receptor of IL-2Ralpha, IL-2Rbeta, and the common gamma chain, activating JAK1 and JAK3 with STAT5 to control regulatory T cell fitness, effector CD8 expansion, and activation induced cell death. Because high-affinity capture depends on constitutive CD25 on regulatory T cells, interleukin 2 availability is a tolerance checkpoint, and germline Il2 or Il2ra nulls develop lethal lymphoproliferation with autoimmune hemolytic anemia and colitis rather than immunodeficiency, a phenotype that constrains any breeding scheme. Allele class should follow the endpoint: conditional deletion in CD4 T cells asks who supplies the cytokine, knockins encoding not-alpha or CD25-biased muteins model low dose interleukin 2 therapy, and humanization supports aldesleukin and engineered agonist pharmacology. Plan drivers early, since Cd4-Cre, Foxp3-Cre, and inducible CreERT2 lines give very different windows on tolerance versus antitumor expansion.
Plan cohort immunophenotyping carefully because background alleles interact with Il2 dependent processes.
What Il2 Immunodeficient mouse models are available?
ingenious targeting laboratory offers 1 distinct Il2 immunodeficient catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| hIL2-Tg(M-NSG) | NSG | Target-Humanized, Immunodeficient, Random Transgenic | LIVE | NSG 010 | Inquire |
| These transgenic mice carry humanized IL2. | |||||
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Pricing and quotes
The Il2 Immunodeficient lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Il2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Il2 Immunodeficient mouse models are available?
When Il2 Immunodeficient lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Il2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Il2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Il2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Il2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ingenious targeting laboratory
Send the Il2 Immunodeficient line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.