Il22 Knockin mouse models
Encoding an interleukin 10 family cytokine, Il22 corresponds to human IL22 and signals through IL-22RA1 paired with the shared IL10RB chain, a receptor configuration restricted to epithelial and hepatocyte compartments, which makes interleukin 22 a lymphocyte to epithelium messenger rather than an immune amplifier. STAT3 activation induces antimicrobial Reg3b and Reg3g, mucins, tight junction components, and hepatocyte acute phase and regenerative programs, while the soluble decoy encoded by Il22ra2 sets bioavailability. Producers include Th17 and Th22 cells, gamma delta T cells, and ILC3s, and the same pathway that protects intestinal stem cells after injury drives keratinocyte hyperproliferation in psoriasis, so context determines whether interleukin 22 is protective or pathogenic. Conditional nulls with Rorc-Cre or Cd4-Cre attribute the source, Il22ra2 alleles test decoy control, and humanization enables agonist as well as neutralizing antibody programs. Microbiota state strongly modifies every readout here, so littermate controlled cohorts and defined flora are essential.
Il22 knockin models place a defined sequence at the endogenous locus. Expression stays under native regulation, which matters for reporters, tags, and precise allele swaps.
What Il22 Knockin mouse models are available?
ingenious targeting laboratory offers 1 distinct Il22 knockin catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Il22-Cre | Knockin | Cre/Dre Toolbox of Mice | live | KI 200167 | Inquire |
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The Il22 Knockin lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Il22 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Il22 Knockin mouse models are available?
When Il22 Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Il22 knockout embryonic lethal in mice?
It depends on background and allele design. Some Il22 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Il22 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Il22?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.