Conventional / global / constitutive KO
●4 Models Available
Il22 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Il22 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il22 conditional knockout mouse, Il22 knockin mouse, Il22 knockout mouse. Request a quote within 24 hours.
Why model Il22
Encoding an interleukin 10 family cytokine, Il22 corresponds to human IL22 and signals through IL-22RA1 paired with the shared IL10RB chain, a receptor configuration restricted to epithelial and hepatocyte compartments, which makes interleukin 22 a lymphocyte to epithelium messenger rather than an immune amplifier. STAT3 activation induces antimicrobial Reg3b and Reg3g, mucins, tight junction components, and hepatocyte acute phase and regenerative programs, while the soluble decoy encoded by Il22ra2 sets bioavailability. Producers include Th17 and Th22 cells, gamma delta T cells, and ILC3s, and the same pathway that protects intestinal stem cells after injury drives keratinocyte hyperproliferation in psoriasis, so context determines whether interleukin 22 is protective or pathogenic. Conditional nulls with Rorc-Cre or Cd4-Cre attribute the source, Il22ra2 alleles test decoy control, and humanization enables agonist as well as neutralizing antibody programs. Microbiota state strongly modifies every readout here, so littermate controlled cohorts and defined flora are essential.
What Il22 mouse models are available?
ingenious targeting laboratory offers 4 distinct Il22 (IL22) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il22 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il22 allele types
Knockout, conditional, knockin, humanized, and related paths for Il22 (human IL22). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il22 catalog models
4 Il22 lines with QC documentation and technical support. Il22 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Il22 mouse model?
We have 4 Il22 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il22 Mouse Model Types
A Il22 knockout mouse has the Il22 gene permanently inactivated, enabling loss of function studies. A Il22 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il22, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il22 knockin models carry a precisely inserted sequence at the Il22 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il22 organized by modification type. Each URL is indexable and matches common search patterns.