Il23a Knockin mouse models
Il23a, the mouse ortholog of human IL23A, encodes the p19 subunit that heterodimerizes with p40 to form interleukin 23, which signals through IL-23R and IL-12Rbeta1 to activate JAK2 and STAT3, stabilizing the RORgt dependent transcriptional program of Th17 cells, gamma delta T17 cells, and ILC3s and sustaining interleukin 17 and interleukin 22 output. Human genetics validates the axis precisely, since the IL23R R381Q variant is protective in psoriasis, ankylosing spondylitis, and Crohn disease, and selective p19 antibodies including risankizumab and guselkumab outperform p40 blockade in skin disease. Because p19 is unique to interleukin 23 while p40 is shared with interleukin 12, an Il23a null delivers the clean loss of function that an Il12b null cannot, and pairing the two alleles is the standard way to partition Th1 from Th17 contributions. Add conditional deletion in dendritic cells or macrophages to identify the producing compartment, and humanization for p19 antibody pharmacology.
Targeting Il23a preserves positional context compared with viral or BAC approaches. That helps when you quantify expression or map chromatin.
What Il23a Knockin mouse models are available?
ingenious targeting laboratory offers 1 distinct Il23a knockin catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Il23a-Luc-2A-EGFP | Knockin | fluorescent mouse | embryo cryopreservation | KI 00057 | Inquire |
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The Il23a Knockin lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Il23a allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Il23a Knockin mouse models are available?
When Il23a Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Il23a knockout embryonic lethal in mice?
It depends on background and allele design. Some Il23a germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Il23a animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Il23a?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.