Conventional / global / constitutive KO
●3 Models Available
Il23a Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Il23a mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Il23a conditional knockout mouse, Il23a knockin mouse, Il23a knockout mouse. Contact us for availability and fast turnaround.
Why model Il23a
Il23a, the mouse ortholog of human IL23A, encodes the p19 subunit that heterodimerizes with p40 to form interleukin 23, which signals through IL-23R and IL-12Rbeta1 to activate JAK2 and STAT3, stabilizing the RORgt dependent transcriptional program of Th17 cells, gamma delta T17 cells, and ILC3s and sustaining interleukin 17 and interleukin 22 output. Human genetics validates the axis precisely, since the IL23R R381Q variant is protective in psoriasis, ankylosing spondylitis, and Crohn disease, and selective p19 antibodies including risankizumab and guselkumab outperform p40 blockade in skin disease. Because p19 is unique to interleukin 23 while p40 is shared with interleukin 12, an Il23a null delivers the clean loss of function that an Il12b null cannot, and pairing the two alleles is the standard way to partition Th1 from Th17 contributions. Add conditional deletion in dendritic cells or macrophages to identify the producing compartment, and humanization for p19 antibody pharmacology.
What Il23a mouse models are available?
ingenious targeting laboratory offers 3 distinct Il23a (IL23A) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il23a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il23a allele types
Knockout, conditional, knockin, humanized, and related paths for Il23a (human IL23A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il23a catalog models
3 Il23a lines with QC documentation and technical support. Il23a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Il23a mouse model?
We have 3 Il23a models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il23a Mouse Model Types
A Il23a knockout mouse has the Il23a gene permanently inactivated, enabling loss of function studies. A Il23a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il23a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il23a knockin models carry a precisely inserted sequence at the Il23a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il23a organized by modification type. Each URL is indexable and matches common search patterns.