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Inhba Conditional Knockout mouse models
The inhibin beta A subunit is encoded by Inhba, the mouse ortholog of human INHBA, which supplies the polypeptide that homodimerizes into activin A, heterodimerizes into activin AB, and pairs with the alpha subunit to form inhibin A. Activin A signals through ActRIIA or ActRIIB with ALK4 to phosphorylate SMAD2 and SMAD3, is neutralized extracellularly by follistatin, and drives mesoderm induction, pituitary FSH synthesis, wound repair, heterotopic ossification, and tumor-associated cachexia. Nulls die shortly after birth with cleft palate, absent whiskers, and incisor defects, so conditional deletion is necessary for adult muscle, immune, and cancer endpoints. Subunit-swap knockins, in which Inhbb coding sequence replaces Inhba, remain the cleanest test of whether phenotypes reflect ligand identity or expression domain, and humanization enables selectivity testing of anti-activin A antibodies. Because Inhbb partially substitutes through shared receptors, plan compound conditional genetics before attributing a phenotype to activin A alone.
Conditional deletion of Inhba limits the genetic change to the lineage you choose. That helps in oncology, immunology, and metabolic work where systemic loss would muddy the read. After you confirm Cre specificity, crossing to Inhba floxed stock yields usable cohorts.
What Inhba Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Inhba conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Inhba-Flox | CKO | CKO | DEVELOPING | CKO 241563 | Inquire |
| These strains carry loxP sites flanking exon 5 of Inhba gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Inhba gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Inhba Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Inhba allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Inhba Conditional Knockout mouse models are available?
When Inhba Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Inhba knockout embryonic lethal in mice?
It depends on background and allele design. Some Inhba germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Inhba animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Inhba?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ITL
Send the Inhba Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.