Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
DEVELOPING
Inhba Conditional Knockout mouse model
Browse 1 Inhba mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Inhba
The inhibin beta A subunit is encoded by Inhba, the mouse ortholog of human INHBA, which supplies the polypeptide that homodimerizes into activin A, heterodimerizes into activin AB, and pairs with the alpha subunit to form inhibin A. Activin A signals through ActRIIA or ActRIIB with ALK4 to phosphorylate SMAD2 and SMAD3, is neutralized extracellularly by follistatin, and drives mesoderm induction, pituitary FSH synthesis, wound repair, heterotopic ossification, and tumor-associated cachexia. Nulls die shortly after birth with cleft palate, absent whiskers, and incisor defects, so conditional deletion is necessary for adult muscle, immune, and cancer endpoints. Subunit-swap knockins, in which Inhbb coding sequence replaces Inhba, remain the cleanest test of whether phenotypes reflect ligand identity or expression domain, and humanization enables selectivity testing of anti-activin A antibodies. Because Inhbb partially substitutes through shared receptors, plan compound conditional genetics before attributing a phenotype to activin A alone.
What Inhba mouse models are available?
ingenious targeting laboratory offers 1 distinct Inhba (INHBA) catalog mouse model in the TGF-beta/Activin/Nodal family, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Inhba model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Inhba allele types
Knockout, conditional, knockin, humanized, and related paths for Inhba (human INHBA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Inhba catalog models
1 Inhba line with QC documentation and technical support. Inhba floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Inhba-Flox
CKOCKO
These strains carry loxP sites flanking exon 5 of Inhba gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Inhba gene.
In DevelopmentCKO 241563
Looking for a Inhba mouse model?
We have 1 Inhba model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Inhba Mouse Model Types
A Inhba conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Inhba, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Inhba organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Inhba line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.