Inhbe Conditional Knockout mouse models
Inhbe is the mouse ortholog of human INHBE and encodes activin E, a hepatokine transcriptionally induced by the integrated stress response through ATF4 and by nutrient excess, which acts on adipocytes through ALK7 with ActRIIA or ActRIIB to phosphorylate SMAD2 and SMAD3 and restrain lipolysis. Human predicted loss-of-function alleles are protective, lowering waist-to-hip ratio and improving hepatic and glycemic measures, which positions the gene as a target where the therapeutic hypothesis is inhibition rather than replacement. That logic favors hepatocyte-restricted conditional nulls to confirm the liver as the obligate source, precise knockins of the human protective variants to test whether they abolish secretion or receptor engagement, and humanized alleles for antibody, siRNA, or antisense pharmacology. Inhbc is an adjacent, coexpressed paralog capable of comparable subunit pairing, so compound alleles and careful floxing that preserves the shared regulatory landscape are needed before adipose lipolysis endpoints are read as definitive.
Conditional deletion of Inhbe limits the genetic change to the lineage you choose. That helps in oncology, immunology, and metabolic work where systemic loss would muddy the read. After you confirm Cre specificity, crossing to Inhbe floxed stock yields usable cohorts.
What Inhbe Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Inhbe conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Inhbe-Flox | Conditional Knockout | KO/CKO mice | live | CKO 252128 | Inquire |
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Inhbe Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Inhbe allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Inhbe Conditional Knockout mouse models are available?
When Inhbe Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Inhbe knockout embryonic lethal in mice?
It depends on background and allele design. Some Inhbe germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Inhbe animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Inhbe?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.