Conventional / global / constitutive KO
●2 Models Available
Inhbe Conditional Knockout, Knockout mouse models
Browse 2 Inhbe mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Inhbe conditional knockout mouse, Inhbe knockout mouse. Request a quote within 24 hours.
Why model Inhbe
Inhbe is the mouse ortholog of human INHBE and encodes activin E, a hepatokine transcriptionally induced by the integrated stress response through ATF4 and by nutrient excess, which acts on adipocytes through ALK7 with ActRIIA or ActRIIB to phosphorylate SMAD2 and SMAD3 and restrain lipolysis. Human predicted loss-of-function alleles are protective, lowering waist-to-hip ratio and improving hepatic and glycemic measures, which positions the gene as a target where the therapeutic hypothesis is inhibition rather than replacement. That logic favors hepatocyte-restricted conditional nulls to confirm the liver as the obligate source, precise knockins of the human protective variants to test whether they abolish secretion or receptor engagement, and humanized alleles for antibody, siRNA, or antisense pharmacology. Inhbc is an adjacent, coexpressed paralog capable of comparable subunit pairing, so compound alleles and careful floxing that preserves the shared regulatory landscape are needed before adipose lipolysis endpoints are read as definitive.
What Inhbe mouse models are available?
ingenious targeting laboratory offers 2 distinct Inhbe (INHBE) catalog mouse models in the TGF-beta/Activin/Nodal family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Inhbe model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Inhbe allele types
Knockout, conditional, knockin, humanized, and related paths for Inhbe (human INHBE). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Inhbe mouse model?
We have 2 Inhbe models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Inhbe Mouse Model Types
A Inhbe knockout mouse has the Inhbe gene permanently inactivated, enabling loss of function studies. A Inhbe conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Inhbe, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Inhbe organized by modification type. Each URL is indexable and matches common search patterns.