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Jak1 Knockout mouse models
Jak1, the mouse ortholog of human JAK1, encodes a nonreceptor tyrosine kinase organized into a FERM domain, an SH2-like module, a catalytically inactive pseudokinase that autoinhibits, and the active kinase domain; it docks on box1 and box2 motifs of type I and type II interferon receptors, gp130-family receptors, and gamma-common cytokine receptors, then phosphorylates receptor tails and Stat1, Stat3, and Stat5 to license dimerization and nuclear import. Homozygous nulls die perinatally with failure to nurse and neurological deficits, so conditional deletion is required for immune and tumor studies, while pseudokinase-domain activating knockins found in acute lymphoblastic leukemia test ligand-independent signaling and kinase-dead alleles separate catalysis from receptor scaffolding. Humanization is the design that supports selectivity profiling of JAK1-biased inhibitors, since paralog-specific pharmacology is the central question. Jak2, Jak3, and Tyk2 pair with distinct receptor chains and do not broadly substitute, though shared receptor complexes can blunt single-gene phenotypes.
Global Jak1 deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Jak1 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Jak1 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Jak1-KO | KO | KO | DEVELOPING | KO 262552 | Inquire |
| The exon 3 of Jak1 gene was deleted to generate Jak1 knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Jak1 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Jak1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Jak1 Knockout mouse models are available?
When Jak1 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Jak1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Jak1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Jak1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Jak1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Jak1 Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.