Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
DEVELOPING · IN PRODUCTION
Jak1 Conditional Knockout, Knockout mouse models
Browse 2 Jak1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Jak1 conditional knockout mouse, Jak1 knockout mouse. Request a quote within 24 hours.
Why model Jak1
Jak1, the mouse ortholog of human JAK1, encodes a nonreceptor tyrosine kinase organized into a FERM domain, an SH2-like module, a catalytically inactive pseudokinase that autoinhibits, and the active kinase domain; it docks on box1 and box2 motifs of type I and type II interferon receptors, gp130-family receptors, and gamma-common cytokine receptors, then phosphorylates receptor tails and Stat1, Stat3, and Stat5 to license dimerization and nuclear import. Homozygous nulls die perinatally with failure to nurse and neurological deficits, so conditional deletion is required for immune and tumor studies, while pseudokinase-domain activating knockins found in acute lymphoblastic leukemia test ligand-independent signaling and kinase-dead alleles separate catalysis from receptor scaffolding. Humanization is the design that supports selectivity profiling of JAK1-biased inhibitors, since paralog-specific pharmacology is the central question. Jak2, Jak3, and Tyk2 pair with distinct receptor chains and do not broadly substitute, though shared receptor complexes can blunt single-gene phenotypes.
What Jak1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Jak1 (JAK1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Jak1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Jak1 allele types
Knockout, conditional, knockin, humanized, and related paths for Jak1 (human JAK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Jak1 catalog models
2 Jak1 lines with QC documentation and technical support. Jak1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Jak1-Flox
CKOCKO
These mice carry loxP sites flanking exon 3 of Jak1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Jak1 gene.
In production — inquireCKO 260688 - Order
Jak1-KO
KOKO
The exon 3 of Jak1 gene was deleted to generate Jak1 knockout mouse.
In DevelopmentKO 262552
Looking for a Jak1 mouse model?
We have 2 Jak1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Jak1 Mouse Model Types
A Jak1 knockout mouse has the Jak1 gene permanently inactivated, enabling loss of function studies. A Jak1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Jak1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Jak1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Jak1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.