Jak2 Humanized Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
Jak2 is a common request for humanized mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat Jak2 Humanized mouse models are available?
ingenious targeting laboratory designs and generates Jak2 humanized mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
Jak2 is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
5 existing alleles are indexed for Jak2, including 1 conditional, including 1 knockout. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Humanization replaces mouse coding sequence with human ortholog sequence at the endogenous locus while keeping native regulatory context. Gene targeting documents junctions and expression before germline transmission.
Human ortholog JAK2 guides humanization design so human coding sequence replaces the mouse exons under endogenous control.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
- Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms.
FAQ
What Jak2 Humanized mouse models are available?
When Jak2 Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Jak2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Jak2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Jak2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Jak2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.