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Kcnj15 Conditional Knockout mouse models
Kcnj15, the mouse ortholog of human KCNJ15, encodes Kir4.2, an inwardly rectifying potassium channel closely related to Kir4.1 that assembles as a homotetramer or, more commonly in native tissue, as a heteromer with Kir5.1 encoded by Kcnj16, an arrangement that confers steep sensitivity to intracellular pH and carbon dioxide. Kir4.2 is expressed on the basolateral membrane of proximal tubule and other kidney segments, in liver, pancreas, and lung, and in restricted neural populations, where it contributes to potassium recycling that supports electrogenic transport and to acid-base sensing. The gene lies within the Down syndrome critical region on human chromosome 21 and has been linked to glucose handling and diabetic nephropathy risk. Conditional nulls with segment-restricted Cre drivers are the appropriate design for transport phenotypes, while pH-sensing residue knockins test the chemosensory hypothesis directly. Because Kir4.1 covers overlapping territory in some tissues, quantify heteromer composition rather than assuming a clean single-subunit loss.
Kcnj15 conditional knockout mice carry a floxed allele so you delete function only where Cre is active. The germline allele stays intact until you cross to a tissue specific Cre. Labs reach for this design when a global knockout is lethal, when they need adult onset loss, or when regional redundancy hides a whole body phenotype.
What Kcnj15 Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Kcnj15 conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Kcnj15-Flox | CKO | CKO | IN PRODUCTION | CKO 262067 | Inquire |
| These mice carry loxP sites flanking exon 4 of Kcnj15 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Kcnj15 gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Kcnj15 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Kcnj15 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Kcnj15 Conditional Knockout mouse models are available?
When Kcnj15 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Kcnj15 knockout embryonic lethal in mice?
It depends on background and allele design. Some Kcnj15 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Kcnj15 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Kcnj15?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Kcnj15 Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.