Kcnq1 Knockout mouse models
Kcnq1, the mouse ortholog of human KCNQ1, encodes Kv7.1, a voltage-gated potassium channel whose gating is transformed by accessory KCNE subunits: with KCNE1 it produces the slowly activating cardiac current IKs that provides repolarization reserve during sympathetic drive, while with KCNE3 it becomes a constitutively open conductance supporting chloride secretion in intestinal and airway epithelium. Activity requires PIP2 and calmodulin bound to the carboxy-terminal helices, and PKA phosphorylation through yotiao (AKAP9) mediates beta-adrenergic augmentation. Loss-of-function mutations cause long QT syndrome type 1 and, when biallelic, Jervell and Lange-Nielsen syndrome with deafness from failed endolymph secretion in the stria vascularis, whereas gain-of-function alleles cause short QT and atrial fibrillation. Mouse nulls are viable but deaf with vestibular dysfunction and gastric hyperplasia, so tissue-restricted conditional deletion separates cardiac, cochlear, and epithelial endpoints, and humanized knockins are preferred when the readout is IKs pharmacology, since murine repolarization depends on different currents.
A conventional Kcnq1 knockout removes gene function in all cells that inherit the allele. It is a proven first pass for target validation when redundancy is low.
What Kcnq1 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Kcnq1 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Kcnq1-KO | Knockout | KO/CKO mice | embryo cryopreservation | KO 200997 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Kcnq1 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Kcnq1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Kcnq1 Knockout mouse models are available?
When Kcnq1 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Kcnq1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Kcnq1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Kcnq1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Kcnq1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.