Lrp6 Knockout mouse models
Sharing architecture with Lrp5, Lrp6 is the mouse ortholog of human LRP6 and encodes the more broadly required Wnt co-receptor, using its four beta-propeller and EGF repeat modules to engage Wnt ligands alongside Frizzled and its PPPSPXS-containing tail to recruit Axin after CK1gamma and Gsk3 phosphorylation, thereby stabilizing beta-catenin; Dkk1 and Sost bind the amino-terminal propellers, and Mesd chaperones folding during biosynthesis. Homozygous nulls die at or before birth with caudal truncation, neural tube closure defects, and limb abnormalities that phenocopy combined Wnt deficiencies, while the hypomorphic ringelschwanz allele survives with axial skeletal defects, so conditional deletion is the practical route for postnatal bone, metabolic, and tumor studies. Phosphomimetic tail knockins ask whether constitutive Axin capture drives signaling, antagonist-resistant propeller mutants test the Dkk1 axis genetically, and humanization supports antibody development. Because Lrp5 partially compensates in bone, plan compound conditional genetics with a skeletal or intestinal driver.
Lrp6 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Lrp6 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Lrp6 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Lrp6-KO | Knockout | KO/CKO mice | sperm cryopreservation | KO 250423 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Lrp6 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Lrp6 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Lrp6 Knockout mouse models are available?
When Lrp6 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Lrp6 knockout embryonic lethal in mice?
It depends on background and allele design. Some Lrp6 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Lrp6 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Lrp6?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.