Conventional / global / constitutive KO
●2 Models Available
Lrp6 Conditional Knockout, Knockout mouse models
Browse 2 Lrp6 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Lrp6 conditional knockout mouse, Lrp6 knockout mouse. Contact us for availability and fast turnaround.
Why model Lrp6
Sharing architecture with Lrp5, Lrp6 is the mouse ortholog of human LRP6 and encodes the more broadly required Wnt co-receptor, using its four beta-propeller and EGF repeat modules to engage Wnt ligands alongside Frizzled and its PPPSPXS-containing tail to recruit Axin after CK1gamma and Gsk3 phosphorylation, thereby stabilizing beta-catenin; Dkk1 and Sost bind the amino-terminal propellers, and Mesd chaperones folding during biosynthesis. Homozygous nulls die at or before birth with caudal truncation, neural tube closure defects, and limb abnormalities that phenocopy combined Wnt deficiencies, while the hypomorphic ringelschwanz allele survives with axial skeletal defects, so conditional deletion is the practical route for postnatal bone, metabolic, and tumor studies. Phosphomimetic tail knockins ask whether constitutive Axin capture drives signaling, antagonist-resistant propeller mutants test the Dkk1 axis genetically, and humanization supports antibody development. Because Lrp5 partially compensates in bone, plan compound conditional genetics with a skeletal or intestinal driver.
What Lrp6 mouse models are available?
ingenious targeting laboratory offers 2 distinct Lrp6 (LRP6) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Lrp6 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Lrp6 allele types
Knockout, conditional, knockin, humanized, and related paths for Lrp6 (human LRP6). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Lrp6 catalog models
2 Lrp6 lines with QC documentation and technical support. Lrp6 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Lrp6 mouse model?
We have 2 Lrp6 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Lrp6 Mouse Model Types
A Lrp6 knockout mouse has the Lrp6 gene permanently inactivated, enabling loss of function studies. A Lrp6 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Lrp6, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Lrp6 organized by modification type. Each URL is indexable and matches common search patterns.