Men1 Knockout mouse models
Endocrine tumor suppression centers on Men1, the mouse ortholog of human MEN1, encoding menin, a nuclear scaffold with no intrinsic enzymatic activity that binds the N-terminal fragment of KMT2A and KMT2B to direct H3K4 trimethylation at targets including Cdkn2c and Cdkn1b, while also restraining JUND-dependent transcription and engaging the SMAD3 and beta-catenin axes. Germline heterozygous loss-of-function alleles followed by somatic second hits produce multiple endocrine neoplasia type 1, with parathyroid hyperplasia, gastroenteropancreatic neuroendocrine tumors, and anterior pituitary adenomas, a textbook two-hit mechanism. Homozygous germline deletion is embryonic lethal in midgestation, so heterozygotes supply spontaneous multiendocrine tumor cohorts while conditional nulls driven by Rip-cre, Pdx1-cre, or Gcg-cre restrict loss to beta or alpha cells, shortening latency with clean cell of origin attribution. Because menin also physically gates MLL fusion oncoprotein chromatin occupancy, menin-MLL inhibitor pharmacology is best interrogated with humanized or interface point mutant alleles rather than nulls.
Global Men1 deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Men1 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Men1 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Men1-KO | Knockout | KO/CKO mice | embryo cryopreservation | KO 225069 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Men1 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Men1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Men1 Knockout mouse models are available?
When Men1 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Men1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Men1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Men1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Men1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.