Conventional / global / constitutive KO
●2 Models Available
Men1 Conditional Knockout, Knockout mouse models
Browse 2 Men1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Men1 conditional knockout mouse, Men1 knockout mouse. Contact us for availability and fast turnaround.
Why model Men1
Endocrine tumor suppression centers on Men1, the mouse ortholog of human MEN1, encoding menin, a nuclear scaffold with no intrinsic enzymatic activity that binds the N-terminal fragment of KMT2A and KMT2B to direct H3K4 trimethylation at targets including Cdkn2c and Cdkn1b, while also restraining JUND-dependent transcription and engaging the SMAD3 and beta-catenin axes. Germline heterozygous loss-of-function alleles followed by somatic second hits produce multiple endocrine neoplasia type 1, with parathyroid hyperplasia, gastroenteropancreatic neuroendocrine tumors, and anterior pituitary adenomas, a textbook two-hit mechanism. Homozygous germline deletion is embryonic lethal in midgestation, so heterozygotes supply spontaneous multiendocrine tumor cohorts while conditional nulls driven by Rip-cre, Pdx1-cre, or Gcg-cre restrict loss to beta or alpha cells, shortening latency with clean cell of origin attribution. Because menin also physically gates MLL fusion oncoprotein chromatin occupancy, menin-MLL inhibitor pharmacology is best interrogated with humanized or interface point mutant alleles rather than nulls.
What Men1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Men1 (MEN1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Men1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Men1 allele types
Knockout, conditional, knockin, humanized, and related paths for Men1 (human MEN1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Men1 catalog models
2 Men1 lines with QC documentation and technical support. Men1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Men1 mouse model?
We have 2 Men1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Men1 Mouse Model Types
A Men1 knockout mouse has the Men1 gene permanently inactivated, enabling loss of function studies. A Men1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Men1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Men1 organized by modification type. Each URL is indexable and matches common search patterns.