Mrc1 Knockin mouse models
Mrc1 corresponds to human MRC1 and encodes the mannose receptor CD206, a type I transmembrane endocytic lectin built from an N-terminal cysteine-rich domain that binds sulfated sugars, a fibronectin type II domain that binds collagen, and eight C-type lectin-like domains of which only a subset ligates terminal mannose, fucose, and N-acetylglucosamine in a calcium dependent manner. It functions constitutively in clathrin mediated uptake and lysosomal delivery, clearing circulating lysosomal hydrolases, thyroglobulin, and collagen fragments and shuttling glycosylated antigen for presentation, and it is expressed by tissue macrophages, lymphatic and hepatic sinusoidal endothelium, and tumor associated macrophages. Nulls are viable with elevated serum lysosomal enzymes, so the interesting alleles are usually reporter or Cre knockins for tracking and manipulating alternatively activated macrophages. Note that endothelial expression makes CD206 an imperfect macrophage restricted driver, and that Mrc2 and scavenger receptors share collagen internalization, so single deletion underestimates clearance.
Mrc1 knockin models place a defined sequence at the endogenous locus. Expression stays under native regulation, which matters for reporters, tags, and precise allele swaps.
What Mrc1 Knockin mouse models are available?
ingenious targeting laboratory offers 1 distinct Mrc1 (CD206) knockin catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Mrc1-2A-CreERT2 | Knockin | Cre/Dre Toolbox of Mice | live | KI 220031 | Inquire |
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The Mrc1 Knockin lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Mrc1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Mrc1 Knockin mouse models are available?
When Mrc1 Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Mrc1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Mrc1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Mrc1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Mrc1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.