Conventional / global / constitutive KO
●6 Models Available
READY TO SHIP!
LIVE · EMBRYO · DEVELOPING · IN PRODUCTION
Mrc1 Conditional Knockout, Knockin, Knockout mouse models
Browse 6 Mrc1 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Mrc1 conditional knockout mouse, Mrc1 knockin mouse, Mrc1 knockout mouse. Request a quote within 24 hours.
Why model Mrc1
Mrc1 corresponds to human MRC1 and encodes the mannose receptor CD206, a type I transmembrane endocytic lectin built from an N-terminal cysteine-rich domain that binds sulfated sugars, a fibronectin type II domain that binds collagen, and eight C-type lectin-like domains of which only a subset ligates terminal mannose, fucose, and N-acetylglucosamine in a calcium dependent manner. It functions constitutively in clathrin mediated uptake and lysosomal delivery, clearing circulating lysosomal hydrolases, thyroglobulin, and collagen fragments and shuttling glycosylated antigen for presentation, and it is expressed by tissue macrophages, lymphatic and hepatic sinusoidal endothelium, and tumor associated macrophages. Nulls are viable with elevated serum lysosomal enzymes, so the interesting alleles are usually reporter or Cre knockins for tracking and manipulating alternatively activated macrophages. Note that endothelial expression makes CD206 an imperfect macrophage restricted driver, and that Mrc2 and scavenger receptors share collagen internalization, so single deletion underestimates clearance.
What Mrc1 mouse models are available?
ingenious targeting laboratory offers 6 distinct Mrc1 (CD206) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 6 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mrc1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mrc1 allele types
Knockout, conditional, knockin, humanized, and related paths for Mrc1 (human MRC1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mrc1 catalog models
6 Mrc1 lines with QC documentation and technical support. Mrc1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Mrc1-Flox
CKOCKO
These mice carry loxP sites flanking exon 8-9 of Mrc1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Mrc1 gene.
In production — inquireCKO 260123 - Order
Mrc1-IRES-mCherry
KIOther
The IRES-mCherry expression cassette was knocked into the Mrc1 gene stop codon site.
In DevelopmentKI 263635 - Order
Mrc1-mCherry
KIOther
The Kozak-mCherry-WPRE-pA expression cassette was knocked into the Mrc1 gene start codon site.
In DevelopmentKI 263630 - Order
Mrc1-2A-CreERT2
KICre/Dre Toolbox
2A-CreERT2 expression cassette was knocked into the Mrc1 gene stop codon site.
LiveKI 220031 - Order
Mrc1-2A-mCherry
KIFluorescent Model
The 2A-mcherry expression cassette was knocked into the Mrc1 gene stop codon site.
In DevelopmentKI 232199 - Order
Mrc1-KO
KOKO
This Mrc1 knockout mouse model was generated by knocking out the exon7-8 region of the Mrc1.
Embryo CryopreservedKO 190228
Looking for a Mrc1 mouse model?
We have 6 Mrc1 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model6
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mrc1 Mouse Model Types
A Mrc1 knockout mouse has the Mrc1 gene permanently inactivated, enabling loss of function studies. A Mrc1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mrc1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Mrc1 knockin models carry a precisely inserted sequence at the Mrc1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Mrc1 organized by modification type. Each URL is indexable and matches common search patterns.
Related Gene Targets
Breed this line with ingenious targeting laboratory
Send the Mrc1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.