Conventional / global / constitutive KO
●3 Models Available
Mrc1 Knockin, Knockout, Xenograft-Applicable mouse models
Browse 3 Mrc1 mouse models including knockin, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Mrc1 knockin mouse, Mrc1 knockout mouse, Mrc1 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Mrc1
Mrc1 corresponds to human MRC1 and encodes the mannose receptor CD206, a type I transmembrane endocytic lectin built from an N-terminal cysteine-rich domain that binds sulfated sugars, a fibronectin type II domain that binds collagen, and eight C-type lectin-like domains of which only a subset ligates terminal mannose, fucose, and N-acetylglucosamine in a calcium dependent manner. It functions constitutively in clathrin mediated uptake and lysosomal delivery, clearing circulating lysosomal hydrolases, thyroglobulin, and collagen fragments and shuttling glycosylated antigen for presentation, and it is expressed by tissue macrophages, lymphatic and hepatic sinusoidal endothelium, and tumor associated macrophages. Nulls are viable with elevated serum lysosomal enzymes, so the interesting alleles are usually reporter or Cre knockins for tracking and manipulating alternatively activated macrophages. Note that endothelial expression makes CD206 an imperfect macrophage restricted driver, and that Mrc2 and scavenger receptors share collagen internalization, so single deletion underestimates clearance.
What Mrc1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Mrc1 (CD206) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Mrc1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mrc1 allele types
Knockout, conditional, knockin, humanized, and related paths for Mrc1 (human MRC1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mrc1 catalog models
3 Mrc1 lines with QC documentation and technical support.
Looking for a Mrc1 mouse model?
We have 3 Mrc1 models in stock — including Knockin, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mrc1 Mouse Model Types
A Mrc1 knockout mouse has the Mrc1 gene permanently inactivated, enabling loss of function studies. Mrc1 knockin models carry a precisely inserted sequence at the Mrc1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Mrc1 organized by modification type. Each URL is indexable and matches common search patterns.