Nrg3 Knockout mouse models
Nrg3, the mouse ortholog of human NRG3, encodes a neuregulin whose EGF-like domain binds Erbb4 essentially exclusively, with no appreciable affinity for Erbb3, giving it unusually selective receptor specificity within the family; it is expressed predominantly in central nervous system neurons, where it acts as a membrane-tethered and shed ligand controlling cortical interneuron migration, axonal outgrowth, and Erbb4-dependent GABAergic synapse formation on parvalbumin interneurons. The spontaneous mouse kyphoscoliosis allele disrupts Nrg3 and produces neuromuscular and skeletal deformity, while human NRG3 variants are associated with schizophrenia and attention deficit phenotypes, and elevated NRG3 expression correlates with cortical dysfunction. Nulls are viable with behavioral and circuit abnormalities, so germline deletion is tractable and conditional alleles restrict loss to specific neuronal populations after migration is complete. EGF-domain substitutions that abolish Erbb4 binding separate ligand activity from structural roles, and because Nrg1 and Nrg2 also engage Erbb4, compound alleles clarify masked synaptic phenotypes.
Nrg3 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Nrg3 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Nrg3 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Nrg3-KO | Knockout | KO/CKO mice, disease model mice | embryo cryopreservation | KO 201022 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Nrg3 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Nrg3 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Nrg3 Knockout mouse models are available?
When Nrg3 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Nrg3 knockout embryonic lethal in mice?
It depends on background and allele design. Some Nrg3 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Nrg3 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Nrg3?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.