Plg Knockout mouse models
Plg, the mouse ortholog of human PLG, encodes plasminogen, a zymogen whose five kringle domains carry lysine binding sites that dock fibrin, cell surface receptors such as Plg-RKT and annexin A2, and carboxy-terminal lysines exposed on partially degraded substrates. Cleavage by tPA or uPA converts closed, activation-resistant Glu-plasminogen into plasmin, which degrades fibrin, activates MMPs, cleaves complement C3 and C5, and liberates matrix-sequestered growth factors, while alpha 2 antiplasmin terminates the reaction. Homozygous nulls survive but develop widespread fibrin deposition, rectal prolapse, delayed wound closure, and growth failure, so complete deletion is informative yet phenotypically dominant, and conditional hepatic deletion or hypomorphic knockins give graded fibrinolytic capacity. Humanized kringle knockins matter for tranexamic acid, plasminogen replacement, or kringle-directed biologics. Match allele to readout, whether clot lysis kinetics, ligneous conjunctivitis, or complement-dependent inflammation.
Whole body loss of Plg gives the clearest readout when the question is whether the gene is required at all. Follow up tissue work can still move to a conditional allele if lethality or compensation appears.
What Plg Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Plg knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Plg-KO | Knockout | KO/CKO mice | live | KO 215098 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Plg Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Plg allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Plg Knockout mouse models are available?
When Plg Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Plg knockout embryonic lethal in mice?
It depends on background and allele design. Some Plg germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Plg animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Plg?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.