Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · EMBRYO
Plg Conditional Knockout, Knockout mouse models
Browse 3 Plg mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Plg conditional knockout mouse, Plg knockout mouse. Request a quote within 24 hours.
Why model Plg
Plg, the mouse ortholog of human PLG, encodes plasminogen, a zymogen whose five kringle domains carry lysine binding sites that dock fibrin, cell surface receptors such as Plg-RKT and annexin A2, and carboxy-terminal lysines exposed on partially degraded substrates. Cleavage by tPA or uPA converts closed, activation-resistant Glu-plasminogen into plasmin, which degrades fibrin, activates MMPs, cleaves complement C3 and C5, and liberates matrix-sequestered growth factors, while alpha 2 antiplasmin terminates the reaction. Homozygous nulls survive but develop widespread fibrin deposition, rectal prolapse, delayed wound closure, and growth failure, so complete deletion is informative yet phenotypically dominant, and conditional hepatic deletion or hypomorphic knockins give graded fibrinolytic capacity. Humanized kringle knockins matter for tranexamic acid, plasminogen replacement, or kringle-directed biologics. Match allele to readout, whether clot lysis kinetics, ligneous conjunctivitis, or complement-dependent inflammation.
What Plg mouse models are available?
ingenious targeting laboratory offers 3 distinct Plg (PLG) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Plg model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Plg allele types
Knockout, conditional, knockin, humanized, and related paths for Plg (human PLG). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Plg catalog models
3 Plg lines with QC documentation and technical support. Plg floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Plg-Flox
CKOCKO
These mice carry loxP sites flanking exon 2 of Plg gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Plg gene.
LiveCKO 253008 - Order
Plg-KO(2)
KOKO
The exon 2 of Plg gene was deleted to generate Plg knockout mouse.
LiveKO 261238 - Order
Plg-KO
KOKO
Exon 15-17 of Plg gene was deleted to generate Plg knockout mice.
Embryo CryopreservedKO 215098
Looking for a Plg mouse model?
We have 3 Plg models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Plg Mouse Model Types
A Plg knockout mouse has the Plg gene permanently inactivated, enabling loss of function studies. A Plg conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Plg, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Plg organized by modification type. Each URL is indexable and matches common search patterns.
Related Gene Targets
Breed this line with ingenious targeting laboratory
Send the Plg line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.