What Plg Knockout mouse models are available?

When Plg Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Plg knockout embryonic lethal in mice?

It depends on background and allele design. Some Plg germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Plg animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Plg?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●1 Model Available

Plg Knockout mouse model

Name: Plg-KO
Brand: ingenious targeting laboratory
SKU: KO 215098
Availability: InStock

Browse 1 Plg mouse model including knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.

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Why model Plg

Plg, the mouse ortholog of human PLG, encodes plasminogen, a zymogen whose five kringle domains carry lysine binding sites that dock fibrin, cell surface receptors such as Plg-RKT and annexin A2, and carboxy-terminal lysines exposed on partially degraded substrates. Cleavage by tPA or uPA converts closed, activation-resistant Glu-plasminogen into plasmin, which degrades fibrin, activates MMPs, cleaves complement C3 and C5, and liberates matrix-sequestered growth factors, while alpha 2 antiplasmin terminates the reaction. Homozygous nulls survive but develop widespread fibrin deposition, rectal prolapse, delayed wound closure, and growth failure, so complete deletion is informative yet phenotypically dominant, and conditional hepatic deletion or hypomorphic knockins give graded fibrinolytic capacity. Humanized kringle knockins matter for tranexamic acid, plasminogen replacement, or kringle-directed biologics. Match allele to readout, whether clot lysis kinetics, ligneous conjunctivitis, or complement-dependent inflammation.

What Plg mouse models are available?

ingenious targeting laboratory offers 1 distinct Plg (PLG) catalog mouse model, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
1 Ready Catalog Line	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Cryo or Live Dispatch Options

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Cryo or Live Dispatch Options

Plg model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
Request a quote
Humanized
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Transgenic / overexpression
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Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Plg allele types

Knockout, conditional, knockin, humanized, and related paths for Plg (human PLG). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

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Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

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Available Plg catalog models

1 Plg line with QC documentation and technical support.

Plg-KO
Knockout
KO/CKO mice
liveKO 215098
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Looking for a Plg mouse model?

We have 1 Plg model in stock — including Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation