Pten Xenograft-Applicable mouse models
Pten is a lipid phosphatase that restrains Pi3K Akt signaling. Loss drives hyperproliferation and survival in many solid tumors while also altering metabolism in liver and brain. Floxed Pten mice made tissue specific cancer models routine long before CRISPR editing was common. A conventional knockout helps when you need strong pathway activation everywhere it is viable, while liver or neural restricted loss models human PTEN syndromes more faithfully. Pairings with Cre drivers remain the standard way to separate developmental compensation from adult disease.
Baseline Pten loss or humanization may change engraftment; pilot cohorts de risk larger studies.
Catalog table
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For liver centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Pten-Flox/Kras-LSL-G12D | Xenograft-Applicable | KO/CKO mice,point mutantion mice | embryo cryopreservation | XA 234944 | Inquire |
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For liver centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Build timeline and pricing
Typical custom projects target study ready cohorts near twenty six weeks from contract start when breeding is direct. Quotes return in about twenty four hours with milestones, pricing, and options for cryo or live dispatch.
Open the request quote formFAQ
How long does a Pten xenograft-applicable project take?
Most custom xenograft-applicable projects run near twenty six weeks from contract activation to study ready animals when breeding is straightforward. Complex humanization or multi allele stacks can add time. We return detailed quotes within about twenty four hours so you can align cohort start dates with grant or IND milestones.
Is Pten knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Pten germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. We prioritize drivers with strong community validation for your tissue.
Do you ship live Pten animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a custom project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Pten?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.