Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
LIVE · EMBRYO
Pten Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 4 Pten mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pten conditional knockout mouse, Pten knockout mouse, Pten xenograft-applicable mouse. Request a quote within 24 hours.
Why model Pten
Antagonism of PI3K signaling is the defining activity of Pten, ortholog of human PTEN, whose phosphatase domain dephosphorylates the 3 position of PIP3 to regenerate PIP2, collapsing PDPK1 and AKT recruitment, while its C2 domain mediates membrane binding and a carboxy-terminal tail with a PDZ-binding motif and phosphorylation cluster controls stability and the open versus closed conformation. Protein phosphatase and nuclear scaffolding activities are separable from lipid phosphatase activity, which is why the G129E lipid-dead and C124S catalytically dead knockins remain more informative than a null for mechanism. Germline deletion is embryonic lethal, and heterozygotes develop a broad tumor spectrum reflecting exquisite dose sensitivity, so conditional nulls and hypomorphic alleles that titrate expression mirror PTEN hamartoma tumor syndrome better than complete loss. Choose accordingly: conditional null with a prostate, mammary or neural Cre driver for tumor latency, missense knockin for variant interpretation and inhibitor pharmacology.
What Pten mouse models are available?
ingenious targeting laboratory offers 4 distinct Pten (PTEN) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Pten model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pten allele types
Knockout, conditional, knockin, humanized, and related paths for Pten (human PTEN). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pten catalog models
4 Pten lines with QC documentation and technical support. Pten floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pten-Flox
CKOCKO, Disease Model
These Pten flox mice possess loxP sites flanking exons 5 via CRISPR/Cas mediated recombination. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.
LiveCKO 18004 - Order
Pten-KO/Rag1-KO(Rag1-EGFP)
KOKO, Fluorescent Model, Immunodeficient
The Pten-KO(KO 18002) was crossed with Rag1-KO(Rag1-EGFP)(KI 00069) to generate Pten-KO/Rag1-KO(Rag1-EGFP) mice.
LiveKO 234524 - Order
Pten-KO
KOKO, Disease Model
Exon5 of Pten gene was deleted to generate Pten knockout mice.
Embryo CryopreservedKO 18002 - Order
Pten-Flox/Kras-LSL-G12D
XAKO, Point Mutation
The Pten-Flox(CKO 18004) was crossed with Kras-LSL-G12D(KI 190003) to generate Pten-Flox/Kras-LSL-G12D mice.
Embryo CryopreservedXA 234944
Looking for a Pten mouse model?
We have 4 Pten models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pten Mouse Model Types
A Pten knockout mouse has the Pten gene permanently inactivated, enabling loss of function studies. A Pten conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pten, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pten organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Pten.
Related Gene Targets
Breed this line with ingenious targeting laboratory
Send the Pten line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.