SCID Other mouse model

Available SCID catalog models

1 SCID line with QC documentation and technical support.

• SCID

  Other

  Immunodeficient, Conventional

  SCID mice, or severe combined immunodeficiency mice, were first identified in 1983 by Bosma M.J. in the United States from the C.B.-17/Icr inbred strain. This condition arises from a mutation in a single recessive gene located on chromosome 16, also termed the SCID gene. SCID mice constitute an inbred homozygous line of C.B-17/IcrJ, exhibiting white coat colouration. This strain displays severe combined immunodeficiency, characterised by the absence of B-cell and T-lymphocyte function. Most homozygotes lack detectable levels of IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA, and their thymus, lymph nodes, and splenic follicles contain almost no lymphocytes. However, the strain possesses normal NK cells, macrophages, and granulocytes. SCID mice are frequently used for inoculation with allogeneic or xenogeneic grafts, making them an ideal model for cell transplantation experiments.

  LiveSM 015
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About SCID Mouse Model Types

Related Gene Targets

Breed this line with ITL

Send the SCID line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.