Slc6a2 Knockout mouse models
Noradrenergic signaling is terminated by Slc6a2, the mouse ortholog of human SLC6A2, encoding the norepinephrine transporter, an SLC6 family sodium and chloride coupled symporter with the LeuT twelve-transmembrane fold that clears released norepinephrine into presynaptic terminals of locus coeruleus and sympathetic neurons and also transports dopamine in cortical regions where dopamine transporter expression is low. NET is the principal target of desipramine, reboxetine, and atomoxetine and a component of cocaine and amphetamine action, and the A457P variant causes orthostatic intolerance through dominant-negative loss of transport. Slc6a2 knockout mice are viable, displaying elevated extracellular norepinephrine, prolonged clearance, altered stress and antidepressant responses, and reduced psychostimulant sensitivity, so constitutive null is a valid baseline. Humanized knockin alleles are particularly valuable because rodent and human transporters differ in inhibitor affinity, making them correct for pharmacology, while conditional alleles paired with Dbh-Cre isolate central from peripheral sympathetic contributions.
Global Slc6a2 deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Slc6a2 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Slc6a2 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Slc6a2-KO | Knockout | KO/CKO mice | sperm cryopreservation | KO 232711 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Slc6a2 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Slc6a2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Slc6a2 Knockout mouse models are available?
When Slc6a2 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Slc6a2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Slc6a2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Slc6a2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Slc6a2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.