Conventional / global / constitutive KO
●2 Models Available
Slc6a2 Conditional Knockout, Knockout mouse models
Browse 2 Slc6a2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Slc6a2 conditional knockout mouse, Slc6a2 knockout mouse. Contact us for availability and fast turnaround.
Why model Slc6a2
Noradrenergic signaling is terminated by Slc6a2, the mouse ortholog of human SLC6A2, encoding the norepinephrine transporter, an SLC6 family sodium and chloride coupled symporter with the LeuT twelve-transmembrane fold that clears released norepinephrine into presynaptic terminals of locus coeruleus and sympathetic neurons and also transports dopamine in cortical regions where dopamine transporter expression is low. NET is the principal target of desipramine, reboxetine, and atomoxetine and a component of cocaine and amphetamine action, and the A457P variant causes orthostatic intolerance through dominant-negative loss of transport. Slc6a2 knockout mice are viable, displaying elevated extracellular norepinephrine, prolonged clearance, altered stress and antidepressant responses, and reduced psychostimulant sensitivity, so constitutive null is a valid baseline. Humanized knockin alleles are particularly valuable because rodent and human transporters differ in inhibitor affinity, making them correct for pharmacology, while conditional alleles paired with Dbh-Cre isolate central from peripheral sympathetic contributions.
What Slc6a2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Slc6a2 (SLC6A2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Slc6a2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Slc6a2 allele types
Knockout, conditional, knockin, humanized, and related paths for Slc6a2 (human SLC6A2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Slc6a2 catalog models
2 Slc6a2 lines with QC documentation and technical support. Slc6a2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Slc6a2 mouse model?
We have 2 Slc6a2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Slc6a2 Mouse Model Types
A Slc6a2 knockout mouse has the Slc6a2 gene permanently inactivated, enabling loss of function studies. A Slc6a2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Slc6a2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Slc6a2 organized by modification type. Each URL is indexable and matches common search patterns.