Stk11 Conditional Knockout mouse — Myh6-CreERT2 pairing
A floxed Stk11 allele paired with Cre gives spatial control that whole body knockouts cannot offer. Labs use this approach to separate developmental roles from adult homeostasis, to model human somatic mutations, and to align with clinical presentations where disease begins in one organ. For cardiac work, plan Cre specificity, reporter crosses, and baseline phenotyping before you scale.
Driver pairing
Myh6-CreERT2 biases toward cardiac. Inducible: yes (tamoxifen).
Catalog options
Conditional knockout keeps heart as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
| Model | Type | Category | Availability | Catalog # | |
|---|---|---|---|---|---|
| Stk11-Flox/R26-CAG-LSL-Luc-2A-EGFP/Kras-LSL-G12D | Conditional Knockout | KO/CKO mice,point mutantion mice, over expression mice, fluorescent mouse | live | CKO 234719 | Inquire |
| Stk11-Flox/R26-CAG-LSL-Luc-2A-EGFP | Conditional Knockout | KO/CKO mice, over expression mice, fluorescent mouse | live | CKO 234717 | Inquire |
| Stk11-Frox | Conditional Knockout | KO/CKO mice, disease model mice | embryo cryopreservation | CKO 200251 | Inquire |
| Stk11-Flox | Conditional Knockout | KO/CKO mice, disease model mice | live | CKO 18014 | Inquire |
Why this approach
Conditional knockout keeps neuron as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Build timeline and pricing
Expect roughly twenty six weeks to study ready animals for many standard conditional crosses after contract start. We return quotes in about twenty four hours and map milestones for genotyping, QC, and dispatch.
Open the request quote formFAQ
How long does a Stk11 conditional knockout project take?
Most custom conditional knockout projects run near twenty six weeks from contract activation to study ready animals when breeding is straightforward. Complex humanization or multi allele stacks can add time. We return detailed quotes within about twenty four hours so you can align cohort start dates with grant or IND milestones.
Is Stk11 knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Stk11 germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for myh6 creert2 focused experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. Your query highlights myh6 creert2 as a primary axis, which we treat as the starting point for driver selection.
Do you ship live Stk11 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a custom project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Stk11?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.