Conventional / global / constitutive KO
●5 Models Available
Stk11 Conditional Knockout, Xenograft-Applicable mouse models
Browse 5 Stk11 mouse models including conditional knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Stk11 conditional knockout mouse, Stk11 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Stk11
Metabolic tumor suppression runs through Stk11, the mouse ortholog of human STK11 (LKB1), a serine and threonine kinase that must complex with the pseudokinase STRADA and the scaffold CAB39 to adopt an active conformation, whereupon it phosphorylates the activation loop threonine of AMPK alpha subunits and of twelve related kinases including the SIK, NUAK, MARK, and BRSK families, linking energy stress to mTORC1 restraint, epithelial polarity, and CRTC-dependent transcription. Germline heterozygous inactivation causes Peutz-Jeghers syndrome with hamartomatous polyposis, and somatic biallelic loss co-occurs with KRAS mutation in lung adenocarcinoma, producing immunologically cold, STING-silenced tumors whose SIK dependence and serine metabolism define distinct vulnerabilities. Germline nulls die in midgestation from vascular and placental defects, so conditional nulls combined with Kras LSL-G12D and viral Cre delivery are the workhorse design, while kinase-dead or Peutz-Jeghers missense knockins separate catalytic from scaffolding function. Choose allele class by endpoint: polyposis, tumor immunophenotype, or metabolic inhibitor response.
What Stk11 mouse models are available?
ingenious targeting laboratory offers 5 distinct Stk11 (LKB1) catalog mouse models, featuring conditional knockout and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Stk11 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Stk11 allele types
Knockout, conditional, knockin, humanized, and related paths for Stk11 (human STK11). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Stk11 catalog models
5 Stk11 lines with QC documentation and technical support. Stk11 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Stk11-Flox/R26-CAG-LSL-Luc-2A-EGFP/Kras-LSL-G12D
Conditional KnockoutKO/CKO mice,point mutantion mice, over expression mice, fluorescent mouse
liveCKO 234719 - Order
Stk11-Flox/R26-CAG-LSL-Luc-2A-EGFP
Conditional KnockoutKO/CKO mice, over expression mice, fluorescent mouse
liveCKO 234717 - Order
Stk11-Flox
Conditional KnockoutKO/CKO mice, disease model mice
embryo cryopreservationCKO 200251 - Order
Stk11-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 18014 - Order
Stk11-Flox/Kras-LSL-G12D
Xenograft-ApplicableKO/CKO mice,point mutantion mice
liveXA 250001
Looking for a Stk11 mouse model?
We have 5 Stk11 models in stock — including Conditional Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
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Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Stk11 Mouse Model Types
A Stk11 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Stk11, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Stk11 organized by modification type. Each URL is indexable and matches common search patterns.