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Tlr1 Conditional Knockout mouse models
Tlr1 is the mouse ortholog of human TLR1 and encodes a leucine-rich repeat receptor that does not act alone but heterodimerizes with TLR2 at the plasma membrane to sense triacylated bacterial lipopeptides, with the crystallographically defined arrangement placing two lipid chains in the TLR2 pocket and the third in a narrow TLR1 channel, after which paired TIR domains recruit TIRAP and MyD88 to activate IRAK4, IRAK1, TRAF6, and NF-kB. Divergence in the lipid-binding pocket means mouse and human receptors differ in sensitivity to synthetic agonists such as Pam3CSK4 and to mycobacterial lipoproteins, the main argument for ectodomain humanization. Nulls are viable and immunocompetent at baseline, so germline deletion is straightforward, while conditional alleles resolve myeloid versus epithelial sensing. Tlr6 covers diacylated ligands through the same TLR2 partner, so interpret single knockouts cautiously and match alleles to bacterial burden, cytokine induction, or adjuvant response endpoints.
A floxed Tlr1 allele paired with Cre gives spatial control that whole body knockouts cannot offer. People use it to separate developmental roles from adult homeostasis, to model somatic mutations, and to match disease that begins in one organ.
What Tlr1 Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Tlr1 conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Tlr1-Flox | CKO | CKO | DEVELOPING | CKO 261858 | Inquire |
| These mice carry loxP sites flanking exon4 of Tlr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tlr1 gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Tlr1 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Tlr1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Tlr1 Conditional Knockout mouse models are available?
When Tlr1 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Tlr1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Tlr1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Tlr1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Tlr1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Tlr1 Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.