Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM · DEVELOPING
Tlr1 Conditional Knockout, Knockout mouse models
Browse 2 Tlr1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Tlr1 conditional knockout mouse, Tlr1 knockout mouse. Contact us for availability and fast turnaround.
Why model Tlr1
Tlr1 is the mouse ortholog of human TLR1 and encodes a leucine-rich repeat receptor that does not act alone but heterodimerizes with TLR2 at the plasma membrane to sense triacylated bacterial lipopeptides, with the crystallographically defined arrangement placing two lipid chains in the TLR2 pocket and the third in a narrow TLR1 channel, after which paired TIR domains recruit TIRAP and MyD88 to activate IRAK4, IRAK1, TRAF6, and NF-kB. Divergence in the lipid-binding pocket means mouse and human receptors differ in sensitivity to synthetic agonists such as Pam3CSK4 and to mycobacterial lipoproteins, the main argument for ectodomain humanization. Nulls are viable and immunocompetent at baseline, so germline deletion is straightforward, while conditional alleles resolve myeloid versus epithelial sensing. Tlr6 covers diacylated ligands through the same TLR2 partner, so interpret single knockouts cautiously and match alleles to bacterial burden, cytokine induction, or adjuvant response endpoints.
What Tlr1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Tlr1 (TLR1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tlr1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tlr1 allele types
Knockout, conditional, knockin, humanized, and related paths for Tlr1 (human TLR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tlr1 catalog models
2 Tlr1 lines with QC documentation and technical support. Tlr1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Tlr1-Flox
CKOCKO
These mice carry loxP sites flanking exon4 of Tlr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tlr1 gene.
In DevelopmentCKO 261858 - Order
Tlr1-KO
KOKO
This Tlr1 knockout mouse model was generated by knocking out the exon 3 region of the Tlr1.
Sperm CryopreservedKO 190163
Looking for a Tlr1 mouse model?
We have 2 Tlr1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tlr1 Mouse Model Types
A Tlr1 knockout mouse has the Tlr1 gene permanently inactivated, enabling loss of function studies. A Tlr1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tlr1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tlr1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Tlr1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.