READY TO SHIP!
DEVELOPING
Tlr2 Xenograft-Applicable mouse models
Encoding a broadly promiscuous pattern recognition receptor, Tlr2 is the mouse ortholog of human TLR2 and uses a horseshoe of leucine-rich repeats with a hydrophobic pocket at the boundary of its central and C-terminal regions to sense bacterial lipoproteins, lipoteichoic acid, peptidoglycan fragments, zymosan, and fungal and parasitic lipids, always as a heterodimer with TLR1 or TLR6 and often assisted by CD14, CD36, or integrin beta 3. Ligand engagement dimerizes the TIR domains, recruits TIRAP and MyD88, and activates IRAK and TRAF6 for NF-kB and MAPK output, with a minor endosomal interferon component. Nulls are viable and highly informative in infection models, so germline deletion is a reasonable default, conditional alleles separate myeloid, epithelial, and astrocyte sensing, and ectodomain humanization supports antagonists that fail to cross-react. Because Tlr1 and Tlr6 partition ligand classes, interpret co-receptor genetics together and target clearance, sterile inflammation, or adjuvant endpoints.
Work with your strain choice to align human tumor models with the immune profile you need.
What Tlr2 Xenograft-Applicable mouse models are available?
ingenious targeting laboratory offers 1 distinct Tlr2 xenograft-applicable catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Tlr2-Flox/Col2a1-2A-CreERT2 | XA | CKO, Cre/Dre Toolbox | DEVELOPING | XA 262482 | Inquire |
| The Tlr2-Flox (CKO 231251) was crossed with Col2a1-2A-CreERT2(KI 18029) to generate Tlr2-Flox/Col2a1-2A-CreERT2 mice. | |||||
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Pricing and quotes
The Tlr2 Xenograft-Applicable lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Tlr2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Tlr2 Xenograft-Applicable mouse models are available?
When Tlr2 Xenograft-Applicable lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Tlr2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Tlr2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Tlr2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Tlr2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Tlr2 Xenograft-Applicable line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.