Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · DEVELOPING
Tlr2 Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 3 Tlr2 mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tlr2 conditional knockout mouse, Tlr2 knockout mouse, Tlr2 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Tlr2
Encoding a broadly promiscuous pattern recognition receptor, Tlr2 is the mouse ortholog of human TLR2 and uses a horseshoe of leucine-rich repeats with a hydrophobic pocket at the boundary of its central and C-terminal regions to sense bacterial lipoproteins, lipoteichoic acid, peptidoglycan fragments, zymosan, and fungal and parasitic lipids, always as a heterodimer with TLR1 or TLR6 and often assisted by CD14, CD36, or integrin beta 3. Ligand engagement dimerizes the TIR domains, recruits TIRAP and MyD88, and activates IRAK and TRAF6 for NF-kB and MAPK output, with a minor endosomal interferon component. Nulls are viable and highly informative in infection models, so germline deletion is a reasonable default, conditional alleles separate myeloid, epithelial, and astrocyte sensing, and ectodomain humanization supports antagonists that fail to cross-react. Because Tlr1 and Tlr6 partition ligand classes, interpret co-receptor genetics together and target clearance, sterile inflammation, or adjuvant endpoints.
What Tlr2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tlr2 (TLR2) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Tlr2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tlr2 allele types
Knockout, conditional, knockin, humanized, and related paths for Tlr2 (human TLR2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tlr2 catalog models
3 Tlr2 lines with QC documentation and technical support. Tlr2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Tlr2-Flox
CKOCKO
These strains carry loxP sites flanking exon 3 of Tlr2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tlr2 gene.
LiveCKO 231251 - Order
Tlr2-KO
KOKO
Exon3 of Tlr2 gene were deleted to generate Tlr2 knockout mice.
LiveKO 18026 - Order
Tlr2-Flox/Col2a1-2A-CreERT2
XACKO, Cre/Dre Toolbox
The Tlr2-Flox (CKO 231251) was crossed with Col2a1-2A-CreERT2(KI 18029) to generate Tlr2-Flox/Col2a1-2A-CreERT2 mice.
In DevelopmentXA 262482
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Tlr2 (TLR2) from ingenious supported projects.
- CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2.Soberman RJ, MacKay CR, Vaine CA, Ryan GB, Cerny AM, Thompson MR, Nikolic B, Primo V, Christmas P, Sheiffele P, Aronov L, Knipe DM, Kurt-Jones EA. (2012). PLoS One 7: e47740
Looking for a Tlr2 mouse model?
We have 3 Tlr2 models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tlr2 Mouse Model Types
A Tlr2 knockout mouse has the Tlr2 gene permanently inactivated, enabling loss of function studies. A Tlr2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tlr2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tlr2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Tlr2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.