Trp53 Conditional Knockout mouse models
Trp53 is the guardian of the genome. Stress signals push this tumor suppressor toward cell cycle arrest, senescence, or apoptosis, so the pathway sits at the center of cancer biology. Mouse models let you test somatic mutation timing, cooperation with Kras or Myc, and therapeutic windows in DNA damage driven disease. Conditional alleles matter because complete loss can reshape development while adult onset deletion better mirrors human oncology. Humanized and point mutant variants support antibody and small molecule programs where epitope fidelity matters.
Trp53 conditional knockout mice carry a floxed allele so you delete function only where Cre recombinase is active. This design keeps the germline allele intact until you cross to a tissue specific Cre. It is often the first choice when a global knockout is lethal, when you need adult onset loss, or when regional redundancy masks a whole body phenotype.
Catalog table
Conditional knockout keeps your target tissue as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Conditional knockout keeps liver as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Trp53-Frox | Conditional Knockout | KO/CKO mice, disease model mice | sperm cryopreservation | CKO 190067 | Inquire |
| Trp53-Flox/Kras-LSL-G12D | Conditional Knockout | KO/CKO mice,point mutantion mice | live | CKO 233079 | Inquire |
| Trp53-Flox | Conditional Knockout | KO/CKO mice, disease model mice | live | CKO 18005 | Inquire |
Why this approach
Conditional knockout keeps your target tissue as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Conditional knockout keeps liver as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Trp53 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Trp53 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
Is Trp53 knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Trp53 germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. We prioritize drivers with strong community validation for your tissue.
Do you ship live Trp53 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a model generation project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Trp53?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.