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Ubqln2 Knockout mouse models
Ubiquilin-2, encoded by X-linked mouse Ubqln2 and orthologous to human UBQLN2, is a proteasome shuttle factor with an N-terminal ubiquitin-like domain that docks the 26S proteasome, central STI1-like chaperone regions that bind hydrophobic and transmembrane segments, a primate-specific PXX repeat region, and a C-terminal UBA domain that captures polyubiquitinated substrates. It thereby delivers misfolded and ribosome-quality-control substrates for degradation, participates in autophagosome maturation, and undergoes phase separation into stress granules. Dominant mutations concentrated in the PXX repeat, including P497H, P506T, and P525S, cause X-linked ALS and frontotemporal dementia with ubiquilin-2-positive inclusions. Because that repeat region is absent in rodents, humanized knockin alleles are essentially required for faithful variant modeling rather than murine point mutations. Conditional or constitutive nulls remain useful for proteostasis flux questions, and functional overlap with Ubqln1 and Ubqln4 means compound alleles may be needed when total shuttle capacity is the endpoint.
Ubqln2 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Ubqln2 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Ubqln2 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Ubqln2-KO | KO | KO | DEVELOPING | KO 262776 | Inquire |
| The exon1 of Ubqln2 gene was deleted to generate Ubqln2 knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Ubqln2 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Ubqln2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Ubqln2 Knockout mouse models are available?
When Ubqln2 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Ubqln2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Ubqln2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Ubqln2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Ubqln2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Ubqln2 Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.