Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
DEVELOPING
Ubqln2 Knockout mouse model
Browse 1 Ubqln2 mouse model including knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Ubqln2
Ubiquilin-2, encoded by X-linked mouse Ubqln2 and orthologous to human UBQLN2, is a proteasome shuttle factor with an N-terminal ubiquitin-like domain that docks the 26S proteasome, central STI1-like chaperone regions that bind hydrophobic and transmembrane segments, a primate-specific PXX repeat region, and a C-terminal UBA domain that captures polyubiquitinated substrates. It thereby delivers misfolded and ribosome-quality-control substrates for degradation, participates in autophagosome maturation, and undergoes phase separation into stress granules. Dominant mutations concentrated in the PXX repeat, including P497H, P506T, and P525S, cause X-linked ALS and frontotemporal dementia with ubiquilin-2-positive inclusions. Because that repeat region is absent in rodents, humanized knockin alleles are essentially required for faithful variant modeling rather than murine point mutations. Conditional or constitutive nulls remain useful for proteostasis flux questions, and functional overlap with Ubqln1 and Ubqln4 means compound alleles may be needed when total shuttle capacity is the endpoint.
What Ubqln2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Ubqln2 (UBQLN2) catalog mouse model, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ubqln2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ubqln2 allele types
Knockout, conditional, knockin, humanized, and related paths for Ubqln2 (human UBQLN2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ubqln2 catalog models
1 Ubqln2 line with QC documentation and technical support.
- Order
Ubqln2-KO
KOKO
The exon1 of Ubqln2 gene was deleted to generate Ubqln2 knockout mouse.
In DevelopmentKO 262776
Looking for a Ubqln2 mouse model?
We have 1 Ubqln2 model available — including Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ubqln2 Mouse Model Types
A Ubqln2 knockout mouse has the Ubqln2 gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for Ubqln2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Ubqln2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.