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Uqcrc1 Conditional Knockout mouse models
Uqcrc1 is the mouse ortholog of human UQCRC1 and encodes core protein 1 of complex III, a large matrix-facing subunit that, with core protein 2, adopts a mitochondrial processing peptidase-like fold and forms the structural platform onto which cytochrome b, cytochrome c1 and the Rieske protein assemble in the dimeric bc1 enzyme. These core subunits carry no redox center but are required for holoenzyme stability and for processing events during maturation of the Rieske subunit presequence, so their reduction destabilizes the entire complex and lowers ubiquinol to cytochrome c oxidoreductase flux. Human variants have been linked to complex III deficiency and, separately, reported in familial parkinsonism with dopaminergic vulnerability, making both a conditional null with dopaminergic Cre drivers and a patient-matched missense knockin defensible depending on whether bioenergetic failure or neurodegeneration is the question. Core protein 2 does not substitute. Select blue native assembly, respirometry and dopaminergic histology as paired endpoints.
A floxed Uqcrc1 allele paired with Cre gives spatial control that whole body knockouts cannot offer. People use it to separate developmental roles from adult homeostasis, to model somatic mutations, and to match disease that begins in one organ.
What Uqcrc1 Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Uqcrc1 conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Uqcrc1-Flox | CKO | CKO | IN PRODUCTION | CKO 253687 | Inquire |
| These mice carry loxP sites flanking exon 3-4 of Uqcrc1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Uqcrc1 gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Uqcrc1 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Uqcrc1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Uqcrc1 Conditional Knockout mouse models are available?
When Uqcrc1 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Uqcrc1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Uqcrc1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Uqcrc1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Uqcrc1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Uqcrc1 Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.