Uqcrq Knockout mouse models
Uqcrq, ortholog of human UQCRQ, encodes the small ubiquinone-binding protein subunit of complex III that packs against cytochrome b and helps shape the environment of the quinone sites where the bifurcated Q cycle operates, moving electrons from ubiquinol to the Rieske iron-sulfur protein and to the b hemes. A homozygous missense substitution in this subunit was identified as a cause of severe complex III deficiency with Leigh-like encephalopathy and profound psychomotor impairment, establishing that even a small structural subunit can be rate limiting for holoenzyme function. That makes a patient-matched knockin the most faithful design, since it preserves partial assembly and reproduces graded respiratory chain failure, whereas a floxed conditional null answers the separate question of where complex III abundance constrains oxidative metabolism. No paralogous subunit substitutes at this position. Match allele class to blue native assembly, cytochrome c reductase activity, brain lesion mapping and lactate endpoints using neuronal Cre drivers.
A conventional Uqcrq knockout removes gene function in all cells that inherit the allele. It is a proven first pass for target validation when redundancy is low.
What Uqcrq Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Uqcrq knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Uqcrq-KO | Knockout | KO/CKO mice | sperm cryopreservation | KO 251075 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Uqcrq Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Uqcrq allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Uqcrq Knockout mouse models are available?
When Uqcrq Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Uqcrq knockout embryonic lethal in mice?
It depends on background and allele design. Some Uqcrq germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Uqcrq animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Uqcrq?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.