We build the exact model your study needs.

Designed and delivered by ingenious targeting laboratory. Quote in 24 hours.

Get a Quote
Skip to main content
Uncertain NIH funding? Start now, pay later.

READY TO SHIP!

LIVE · EMBRYO · DEVELOPING

hPD Humanized mouse models

Humanized hPD lines support efficacy and pharmacodynamic studies where the wild type mouse protein would not engage the clinical candidate.

Order catalog model Request a Quote

What hPD Humanized mouse models are available?

ingenious targeting laboratory offers 61 distinct hPD humanized catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model Availability

61 Ready Catalog Lines

Allele Class Options

Humanized

Quality Control Standards

Documented Germline Transmission

Catalog table

ModelTypeCategoryAvailabilityCatalog #Action
hPD-1/hSIRPA(2)HUTarget-HumanizedEMBRYOHU 2000089Inquire
hPD-1(HU 00015) was crossed with hSIRPA(2) (HU 18015) to generate hPD-1/hSIRPA(2).
hPD-L1/hOX40HUTarget-HumanizedEMBRYOHU 00111Inquire
hPD-L1（HU 00062）was crossed with hOX40（HU 00041）to generate hPD-L1/hOX40.
hPD-L1(2)/hCD28HUTarget-HumanizedEMBRYOHU 210370Inquire
hPD-L1(2)(HU 190039) was crossed with hCD28(HU 190011）to generate hPD-L1(2)/hCD28 mice
hPD-L1/hSTINGHUTarget-HumanizedEMBRYOHU 2000105Inquire
hPD-L1(HU 00062) was crossed with hSTING(HU 190036) to generate hPD-L1/hSTING.
hPD-1/hSTINGHUTarget-HumanizedEMBRYOHU 2000104Inquire
hPD-1(HU 00015) was crossed with hSTING(HU 190036) to generate hPD-1/hSTING.
hPD-1(BALB/c)HUTarget-HumanizedLIVEHU 190079Inquire
The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .
hPD-L1(E3-4)HUTarget-HumanizedEMBRYOHU 190039Inquire
Extracellular domain of mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene. While hPD-L1(Stock No.HU 00062) mice function similarly to hPD-L1(2) mice,for more detailed information please contact our technical advisor.
hPD-L2HUTarget-HumanizedEMBRYOHU 190050Inquire
The endogenous mouse Pdcd1lg2 gene was replaced by the human PDCD1LG2 gene.
hPD-1(3)HUTarget-HumanizedLIVEHU 235087Inquire
The endogenous mouse Pdcd1 gene was replaced by human PDCD1 gene.
hPD-1/hPD-L1(2)/hCCR8HUTarget-HumanizedDEVELOPINGHU 210402Inquire
hPD-1(HU 00015) and hPD-1(2)(HU 190039) were crossed with hCCR8(HU 190053) to generate hPD-1/hPD-L1(2)/hCCR8 mice.
hPD-L1/hCD27(2)HUTarget-HumanizedEMBRYOHU 200274Inquire
hPD-L1(HU 00062) was crossed with hCD27(2)(HU 190035)to generate hPD-L1/hCD27(2) mice.While hPD-L1/hCD27 (Stock No.HU 18023) have been pulled from shelves for some reasons.
hPD-L1/hCD28HUTarget-HumanizedEMBRYOHU 210019Inquire
hPD-L1(HU 00062) was crossed with hCD28(HU 190011) to generate hPD-L1/hCD28 mice
hPD-1/hPD-L1/hLAG3HUTarget-HumanizedEMBRYOHU 190028Inquire
hPD-1(HU 00015),hPD-L1(HU 00062) were crossed with hLAG3(HU 00049) to generate hPD-1/hPD-L1/hLAG3.
hPD-1/hPD-L1/hIDO1HUTarget-HumanizedLIVEHU 00120Inquire
hPD-1(HU 00015),hPD-L1(HU 00062) were crossed with hIDO1(HU 00061) to generate hPD-1/hPD-L1/hIDO1.
hPD-1/Cd8a-IRES-Akaluc-2A-EGFPHUFluorescent Model, Target-HumanizedEMBRYOHU 210373Inquire
hPD-1(HU 00015) was crossed with Cd8a-IRES-Luc-2A-EGFP(KI 18030) to generate hPD-1/Cd8a-IRES-Luc-2A-EGFP mice
hPD-1/hPD-L1/hCD73(2)HUTarget-HumanizedEMBRYOHU 210410Inquire
hPD-1(HU 00015) was crossed with hPD-L1/hCD73(2)(HU 210356) to generate hPD-1/hPD-L1/hCD73(2) mice.
hPD-1/hTLR9HUTarget-HumanizedEMBRYOHU 190023Inquire
hPD-1(HU 00015) was crossed with hTLR9(HU 18016) to generate hPD-1/hTLR9.
hPD-1/hPVRIGHUTarget-HumanizedEMBRYOHU 231147Inquire
The hPVRIG(HU 210008) was crossed with hPD-1(HU 00015) to generate hPD-1/hPVRIG mice.
hPD-1/hCCR8(BALB/c,2)HUTarget-HumanizedEMBRYOHU 234063Inquire
The hCCR8(BALB/c)(2)(HU 220501) was crossed with hPD-1(BALB/c)(HU 190079) to generate hPD-1/hCCR8(BALB/c,2) mice.
hPD-1/hICOS(2)HUTarget-HumanizedEMBRYOHU 2000100Inquire
hPD-1(HU 00015) was crossed with hICOS(2)(HU 190030) to generate hPD-1/hICOS(2).
hPD-1/hVEGFR2HUTarget-HumanizedEMBRYOHU 2000098Inquire
hPD-1(HU 00015) was crossed with hKDR(HU 00098) to generate hPD-1/hKDR.
hPD-1/hCD28HUTarget-HumanizedEMBRYOHU 2000097Inquire
hPD-1(HU 00015) was crossed with hCD28(HU 190011) to generate hPD-1/hCD28.
hPD-1/hCD27(2)HUTarget-HumanizedEMBRYOHU 2000096Inquire
hPD-1(HU 00015) was crossed with hCD27(2)(HU 190035) to generate hPD-1/hCD27(2).
hPD-1/hSIGLEC15HUTarget-HumanizedEMBRYOHU 2000093Inquire
hPD-1(HU 00015) was crossed with hSIGLEC15(HU 190037) to generate hPD-1/hSIGLEC15.
hPD-1/hPD-L1/hPD-L2HUTarget-HumanizedEMBRYOHU 190060Inquire
The endogenous mouse Pd-1/Pd-l1/Pdcd1lg2 gene was replaced by human PD-1/PD-L1/PDCD1LG2 gene.
hPD-1/hLAG3HUTarget-HumanizedLIVEHU 00101Inquire
hPD-1(HU 00015) was crossed with hLAG3(HU 00049)to generate hPD-1/hLAG3 mice
hPD-1/hPD-L1HUTarget-HumanizedLIVEHU 00100Inquire
hPD-1(HU 00015) was crossed with hPD-L1(HU 00062)to generate hPD-1/hPD-L1 mice
hPD-1/hCTLA-4HUTarget-Humanized, Disease ModelEMBRYOHU 00079Inquire
hPD-1(HU 00015) was crossed with hCTLA4(HU 00014)to generate hPD-1/hCTLA4 mice
hPD-1/hCTLA-4(BALB/c)HUTarget-HumanizedEMBRYOHU 200277Inquire
hPD-1(HU 190079) was crossed with hCTLA4(2)(HU 190078)to generate hPD-1/hCTLA4 mice
hPD-1HUTarget-HumanizedLIVEHU 00015Inquire
The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .
hPD-1/hSEMA4DHUTarget-HumanizedEMBRYOHU 190033Inquire
hPD-1(HU 00015) was crossed with hSEMA4D(HU 00117) to generate hPD-1/hSEMA4D.
hPD-1/hTIGIT/hTIM3HUTarget-HumanizedEMBRYOHU 190029Inquire
hPD-1(HU 00015),hTIGIT(HU 00053) were crossed with hTIM3(HU 00054) to generate hPD-1/hTIGIT/hTIM3.
hPD-1/hPD-L1/hTIGITHUTarget-HumanizedEMBRYOHU 200267Inquire
hTIGIT（HU 00053）,hPD-1（HU 00015）,hPD-L1（HU 00062）were crossed together to generate hPD-1/hPD-L1/hTIGIT mice
hPD-1/hPD-L1/hCTLA-4HUTarget-HumanizedLIVEHU 200266Inquire
hCTLA4（HU 00014）,hPD-1（HU 00015）,hPD-L1（HU 00062）were crossed together to generate hPD-1/hPD-L1/hCTLA4 mice
hPD-1/hPD-L1/hTIM3HUTarget-HumanizedEMBRYOHU 200264Inquire
hTIM3（HU 00054）,hPD-1（HU 00015）,hPD-L1（HU 00062）were crossed together to generate hPD-1/hPD-L1/hTIM3 mice
hPD-1/hLAG3/hTIGITHUTarget-HumanizedEMBRYOHU 200258Inquire
hPD-1(HU 00015),hTIGIT(HU 00053) were crossed with hLAG3(HU 00049) to generate hPD-1/hLAG3/hTIGIT.
hPD-1/hIL1BHUTarget-HumanizedEMBRYOHU 210018Inquire
hPD-1(HU 00015) was crossed with hIL1B(HU 190047) to generate hPD-1/hIL1B mice
hPD-1/hCD40HUTarget-HumanizedLIVEHU 190017Inquire
hPD-1(HU 00015) was crossed with hCD40(HU 00076) to generate hPD-1/hCD40.
hPD-1/hCD3EHUTarget-HumanizedEMBRYOHU 18021Inquire
hPD-1（HU 00015）was crossed with hCD3E（HU 00114）to generate hPD-1/hCD3E。
hPD-1/hTIGITHUTarget-HumanizedEMBRYOHU 00104Inquire
hPD-1(HU 00015) was crossed with hTIGIT(HU 00053) to generate hPD-1/hTIGIT.
hPD-1/hTIM3HUTarget-HumanizedEMBRYOHU 00103Inquire
hPD-1(HU 00015) was crossed with hTIM3(HU 00054)to generate hPD-1/hTIM3 mice
hPD-1/hOX40HUTarget-HumanizedEMBRYOHU 00108Inquire
hPD-1（HU 00015）was crossed with hOX40（HU 00041）to generate hPD-1/hOX40.
hPD-L1/hVISTAHUTarget-HumanizedEMBRYOHU 2000094Inquire
hPD-L1(HU 00062) was crossed with hVISTA(HU 00118) to generate hPD-L1/hVISTA.
hPD-1/hVISTAHUTarget-HumanizedEMBRYOHU 2000092Inquire
hPD-1(HU 00015) was crossed with hSIRPA(2) (HU 18015) to generate hPD-1/hVISTA.
hPD-L1(2)/hCCR8HUTarget-HumanizedEMBRYOHU 210401Inquire
hPD-1(2)(HU 190039) was crossed with hCCR8(HU 190053) to generate hPD-L1(2)/hCCR8 mice.
hPD-1/hPD-L1/hOX40HUTarget-HumanizedEMBRYOHU 00122Inquire
hPD-1(HU 00015),hPD-L1(HU 00062) were crossed with hOX40(HU 00041) to generate hPD-1/hPD-L1/hOX40.
hPD-L2(BALB/c)HUTarget-HumanizedEMBRYOHU 190061Inquire
The endogenous mouse Pdcd1lg2 gene was replaced by human PDCD1LG2 gene.
hPD-L1/hCTLA-4HUTarget-HumanizedEMBRYOHU 00102Inquire
hPD-L1(HU 00062) was crossed with hCTLA4(HU 00014)to generate hPD-1/hCTLA4 mice
hPD-L1/hSIRPA(2)HUTarget-HumanizedEMBRYOHU 2000099Inquire
hPD-L1(HU 00062) was crossed with hSIRPA(2)(HU 18015) to generate hPD-L1/hSIRPA(2).
hPD-L1HUTarget-HumanizedLIVEHU 00062Inquire
The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene . While hPD-L1(2)(Stock No.HU 190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.
hPD-L1/hSIGLEC15HUTarget-HumanizedEMBRYOHU 2000103Inquire
hPD-L1(HU 00062) was crossed with hSIGLEC15(HU 190037) to generate hPD-L1/hSIGLEC15.
hPD-L1/hVEGFR2HUTarget-HumanizedEMBRYOHU 2000102Inquire
hPD-L1(HU 00062) was crossed with hKDR(HU 00098) to generate hPD-L1/hKDR.
hPD-L1/h4-1BB(2)HUTarget-HumanizedEMBRYOHU 200260Inquire
hPD-L1(HU 00062) was crossed with h4-1BB(2)(HU 190077) to generate hPD-L1/h4-1BB(2).
hPD-L1/hCD73(2)HUTarget-HumanizedEMBRYOHU 210356Inquire
hPD-L1(HU 00062) was crossed with hCD73(2)(HU 200009) to generate hPD-L1/hCD73(2) mice.
hPD-L1/hTIM3HUTarget-HumanizedEMBRYOHU 190056Inquire
hPD-L1(HU 00062) was crossed with hTIM3(HU 00054) to generate hPD-L1/hTIM3.
hPD-L1/hSEMA4DHUTarget-HumanizedEMBRYOHU 190034Inquire
hPD-L1(HU 00062) was crossed with hSEMA4D(HU 00117) to generate hPD-L1/hSEMA4D.
hPD-L1/hTIGITHUTarget-HumanizedEMBRYOHU 18013Inquire
hPD-L1(HU 00062) was crossed with hTIGIT(HU 00053) to generate hPD-L1/hTIGIT.
hPD-L1/hLAG3HUTarget-HumanizedEMBRYOHU 00137Inquire
hPD-L1（HU 00062）was crossed with hLAG3（HU 00049）to generate hPD-L1/hLAG3.
hPD-L1/hCD40HUTarget-HumanizedEMBRYOHU 18024Inquire
hPD-L1(HU 00062) was crossed with hCD40(HU 00076) to generate hPD-L1/hCD40.
hPD-1/hPD-L1(BALB/c)HUTarget-HumanizedEMBRYOHU 220142Inquire
hPD-1(BALB/c)(HU 190079) mice were crossed with hPD-L1(BALB/c ) (HU 220028) mice to generate hPD-1/ hPD-L1(BALB/c) mice.
hPD-L1(BALB/c)HUTarget-HumanizedLIVEHU 220028Inquire
The hPD-L1(E3-4)(HU 190039) mice were backcrossed to BALB/c genetic background, to create the new strain of hPD-L1(BALB/c) (HU 220028) mice.

Why this approach

Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.

Pricing and quotes

The hPD Humanized lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.

If your study needs a hPD allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.

Order a catalog hPD modelRequest a model generation quote

FAQ

What hPD Humanized mouse models are available?

When hPD Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is hPD knockout embryonic lethal in mice?

It depends on background and allele design. Some hPD germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live hPD animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for hPD?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

Related models and routes

All hPD models
hPDGFB HumanizedhPDGFD HumanizedhPDGFRA HumanizedhPDGFRB Humanized

Breed this line with ingenious targeting laboratory

Send the hPD Humanized line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.