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huHSC Humanized mouse models
Humanized huHSC mice substitute the human ortholog sequence so drug binding sites and pathway feedback match the clinic more closely.
What huHSC Humanized mouse models are available?
ingenious targeting laboratory offers 3 distinct huHSC humanized catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| huHSC-(Kit-V831M M-NSG) | HU | Immunodeficient, Point Mutation | LIVE | HU 263011 | Inquire |
| iTL constructed Kit-V831M(NMG) mice by replacing valine (V) with methionine (M) at amino acid position 831 of the mouse Kit gene. Based on this model, human CD34+ HSCs were transplanted into these mice. | |||||
| huHSC-(hIL3/hCSF2 M-NSG) | HU | Target-Humanized, Immunodeficient | LIVE | HU 263008 | Inquire |
| The cytokines IL-3 and GM-CSF are involved in the proliferation and differentiation of myeloid cell precursors. NMG mice transduced with the genes encoding IL-3 and GM-CSF can achieve myeloid cell reconstitution following human hematopoietic stem cell transplantation, presenting a more complete human immune system. | |||||
| huHSC-(NVG-hIL15) | HU | Target-Humanized, Immunodeficient | LIVE | HU 263007 | Inquire |
| Interleukin-15 (IL-15) is essential for the activity, function, and differentiation of NK cells. The expression of human IL-15 in the severely immunodeficient NMG mouse background reduces the differences in immune environment between mice and humans, provides a more suitable survival environment for NK cells, and supports the reconstitution, expansion, and long-term expression of NK cells in vivo. In addition, NVG-hIL15 also supports the reconstitution and expansion of γδ T cells, enabling successful reconstitution with a relatively low injection dose of γδ T cells and extending the survival time of T cells. | |||||
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The huHSC Humanized lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a huHSC allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What huHSC Humanized mouse models are available?
When huHSC Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is huHSC knockout embryonic lethal in mice?
It depends on background and allele design. Some huHSC germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live huHSC animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for huHSC?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ITL
Send the huHSC Humanized line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.