IL22 Mouse Models

Why Model IL22

Il22 is the mouse ortholog of human IL22 and encodes interleukin-22, an IL-10-family cytokine produced by several immune-cell types. IL-22 signals to epithelial cells and has been associated with epithelial barrier function, antimicrobial responses, and tissue repair.

IL-22 has been associated with inflammatory bowel disease, psoriasis, and other conditions, and IL-22-pathway-directed approaches are under study. Il22-deficient mice show altered mucosal responses in disease models.

Model Applications

Humanized IL22 models, in which the human cytokine replaces the mouse counterpart, have been used to evaluate IL-22-pathway-directed agents in defined experimental settings.

Custom IL22 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Interleukin-22: the hub bridging gut homeostasis and metabolism. Trends Immunol. 2025. doi:10.1016/j.it.2025.10.009
• Dumoutier L et al. Human interleukin-10-related T cell-derived inducible factor (IL-TIF): molecular cloning and functional characterization. J Immunol. 2000. doi:10.4049/jimmunol.164.4.1814

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il22ra1 · Il10 · Il17a · Il23a