Il5 Mouse Models

Why Model Il5

Il5 is the mouse ortholog of human IL5 and encodes interleukin-5, a type 2 cytokine produced mainly by T helper 2 cells and group 2 innate lymphoid cells. IL-5 has been associated with the differentiation, survival, and recruitment of eosinophils.

IL-5 is implicated in eosinophilic asthma and other eosinophil-associated diseases, and IL-5-directed antibodies are in clinical use. Il5-deficient mice are viable and show reduced eosinophil responses.

Model Applications

Humanized IL5 models, often paired with the IL-5 receptor, have been used to evaluate IL-5-targeted antibodies in defined experimental settings.

Il5 knockout mice have been used to study eosinophil biology.

Custom Il5 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Efficacy and safety of mepolizumab in severe eosinophilic asthma: a systematic review and meta-analysis. J Thorac Dis. 2025. doi:10.21037/jtd-2025-1596
• Campbell HD et al. Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). Proc Natl Acad Sci U S A. 1987. doi:10.1073/pnas.84.19.6629

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il5ra · Il4 · Il13 · Csf2