Conventional / global / constitutive KO
●3 Models Available
Il5 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Il5 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il5 conditional knockout mouse, Il5 knockin mouse, Il5 knockout mouse. Request a quote within 24 hours.
Why model Il5
Encoding a homodimeric type 2 cytokine, Il5 corresponds to human IL5 and signals through IL-5Ralpha paired with the beta common chain encoded by Csf2rb, shared with interleukin 3 and GM-CSF, activating JAK2 and STAT5 to control eosinophil lineage commitment, marrow release, tissue survival, and B1 cell antibody production. It is the dominant nonredundant eosinophil axis, which is why mepolizumab and reslizumab neutralize the ligand while benralizumab depletes eosinophils by targeting the receptor alpha chain with an afucosylated Fc. The locus sits in the type 2 cluster near Il4 and Il13 under shared regulatory elements, so verify that any targeting cassette does not alter neighboring transcription. Design accordingly: conditional deletion with Cd4-Cre or ILC2 restricted drivers attributes the source, receptor alleles separate development from survival, and humanization supports ligand and receptor antibody pharmacology. Avoid Csf2rb deletion as a proxy, since it also removes interleukin 3 and GM-CSF signaling.
What Il5 mouse models are available?
ingenious targeting laboratory offers 3 distinct Il5 (IL5) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il5 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il5 allele types
Knockout, conditional, knockin, humanized, and related paths for Il5 (human IL5). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il5 catalog models
3 Il5 lines with QC documentation and technical support. Il5 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Il5 mouse model?
We have 3 Il5 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il5 Mouse Model Types
A Il5 knockout mouse has the Il5 gene permanently inactivated, enabling loss of function studies. A Il5 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il5, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il5 knockin models carry a precisely inserted sequence at the Il5 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il5 organized by modification type. Each URL is indexable and matches common search patterns.