Met Mouse Models

Why Model Met

Met is the mouse ortholog of human MET and encodes MET (c-MET), a receptor tyrosine kinase that binds hepatocyte growth factor. MET signaling has been associated with cell proliferation, survival, and migration.

MET alterations, including exon 14 skipping and amplification, have been associated with non-small cell lung cancer and other tumors, and MET inhibitors are used in selected MET-driven cancers; resistance can emerge. Homozygous Met-null mice show embryonic lethality with defects in placenta, liver, and muscle development.

Model Applications

Humanized MET models, in which the human receptor replaces the mouse counterpart, have been used to evaluate MET-targeted antibodies and inhibitors.

Conditional Met models have been used to study MET signaling in defined experimental settings.

Custom Met Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Research progress on resistance and mechanisms of c-Met inhibitors in treating MET exon 14 skipping mutant non-small cell lung cancer: a narrative review. J Thorac Dis. 2026. doi:10.21037/jtd-2026-0949
• Bottaro DP et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 1991. doi:10.1126/science.1846706

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Hgf · Egfr · Erbb2 · Kras