Conventional / global / constitutive KO
●3 Models Available
Met Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Met mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Met conditional knockout mouse, Met knockin mouse, Met knockout mouse. Request a quote within 24 hours.
Why model Met
Receptor tyrosine kinase MET, encoded in mouse by Met, is the single-pass receptor for hepatocyte growth factor, comprising a SEMA domain, PSI and IPT repeats, and a cytoplasmic kinase domain whose phosphorylated Y1349 and Y1356 residues recruit GAB1 and GRB2 to activate RAS-ERK, PI3K-AKT, and STAT3, driving epithelial morphogenesis, hepatocyte survival, and myoblast migration. Oncogenic activation occurs through amplification, exon 14 skipping that removes the CBL-binding juxtamembrane degron and stabilizes the receptor, kinase domain germline mutations such as M1250T in hereditary papillary renal carcinoma, and TPR-MET rearrangement. Germline nulls die near midgestation from placental and hepatic failure, so conditional deletion is required for regeneration and tumor dependency studies, while exon 14 skipping or kinase domain knockins model ligand-independent signaling and inhibitor response. Since HGF binding is species selective, humanized MET or ligand-humanized alleles are essential for antibody and antibody-drug conjugate testing; pair these with epithelial Cre lines matched to the intended tumor lineage.
What Met mouse models are available?
ingenious targeting laboratory offers 3 distinct Met (MET) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Met model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Met allele types
Knockout, conditional, knockin, humanized, and related paths for Met (human MET). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Met catalog models
3 Met lines with QC documentation and technical support. Met floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Met (MET) from ITL supported projects.
- Caspase-6 Controls Lipid and Energy Metabolism in Diet-Induced ObesityGupta A, You W, Han L, Ji J, Pan M, Han X, Sun X, Zhao P. (2026). Adv Sci 21(13):e14784
- Microbiota-dependent formylated peptide receptor (Fpr1/2) signaling regulates enteric nervous system development and gastrointestinal motility in miceChandrasekharan B, Wu H, Smoller C, Kim J, Wolfarth AA, Eboka R, Boyer D, Metzger AJ, Addis CR, Liu K, Srinivasan S, Macpherson AJ, Jones RM, Neish AS. (2025). Cell Mol Gastroenterol Hepatol. 12(19): 101624.
- PGI2 signaling metabolically reprograms CD4 Th2 cells and represses allergic airway inflammationZhou W, Zhang J, Chowdhury NU, Norlander AE, Toki S, Abney M, Rusznak M, Gibson-Corley KN, Cook DP, Newcomb DC, Peebles RS Jr. (2025). J Immunol 9(214): 2270-2280
- A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunityAlexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ. (2024). Cell Rep 11(43):114891
- Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in miceGhosh A, Chénier I, Leung YH, Oppong AK, Peyot, M-L, Madiraju SRM, Al-Khairi I, Abubaker J, Al-Mulla F, Prentki M, Abu-Farha M. (2024). iScience 12(27): 111292
Looking for a Met mouse model?
We have 3 Met models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Met Mouse Model Types
A Met knockout mouse has the Met gene permanently inactivated, enabling loss of function studies. A Met conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Met, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Met knockin models carry a precisely inserted sequence at the Met locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Met organized by modification type. Each URL is indexable and matches common search patterns.