Conventional / global / constitutive KO
●2 Models Available
Pdcd1 Conditional Knockout, Knockin mouse models
Browse 2 Pdcd1 mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pdcd1 conditional knockout mouse, Pdcd1 knockin mouse. Request a quote within 24 hours.
Why model Pdcd1
Pdcd1 encodes PD-1, mouse ortholog of human PDCD1, a single immunoglobulin variable domain inhibitory receptor whose cytoplasmic tail carries an ITIM and, functionally more important, an ITSM that recruits SHP2 to dephosphorylate proximal signaling components, with CD28 rather than the T cell receptor established as the preferred substrate, so PD-1 acts primarily by disabling costimulation. Ligands PD-L1 and PD-L2 are induced by interferon gamma, coupling target cell sensing of inflammation to lymphocyte restraint, and sustained expression marks exhausted CD8 T cells in chronic infection and tumors. Germline nulls develop late, strain dependent autoimmunity, lupus-like nephritis on C57BL/6 and dilated cardiomyopathy on BALB/c, so background must be stated explicitly. Because pembrolizumab and nivolumab do not bind murine PD-1, epitope-matched humanization is mandatory for clinical antibody testing, while conditional nulls with Cd8-Cre address cell intrinsic exhaustion and compound Ctla4 or Lag3 alleles reproduce combination checkpoint synergy.
What Pdcd1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Pdcd1 (PD-1) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pdcd1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pdcd1 allele types
Knockout, conditional, knockin, humanized, and related paths for Pdcd1 (human PDCD1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pdcd1 catalog models
2 Pdcd1 lines with QC documentation and technical support. Pdcd1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Pdcd1 (PDCD1) from ITL supported projects.
- PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunityMao Z, Hirdler JB, Gicobi JK, Maynes M, Hsu MA, Dellacecca ER, Zhang W, Teske JJ, Li Y, Zhao G, Lucien-Matteoni F, da Silva HB, Billadeau DD, Dong H. (2025). bioRxiv.
- Combination CD200R/PD-1 blockade in a humanised mouse model.Fellermeyer M, Anzilotti C, Paluch C, Cornall RJ, Davis SJ, Gileadi U. (2023). Immunother Adv 3(1): ltad006
Looking for a Pdcd1 mouse model?
We have 2 Pdcd1 models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pdcd1 Mouse Model Types
A Pdcd1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pdcd1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Pdcd1 knockin models carry a precisely inserted sequence at the Pdcd1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Pdcd1 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Pdcd1.